{"id":"W4241322874","doi":"10.1182/blood-2019-130534","title":"Cellular and Molecular Architecture of Hematopoietic Stem Cells and Progenitors in Genetic Models of Bone Marrow Failure","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster Children's Hospital; Children's Hospital of Eastern Ontario; Princess Margaret Cancer Centre; Montreal Children's Hospital; University Health Network; BC Children's Hospital; University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Bone marrow failure; Progenitor cell; Bone marrow; Haematopoiesis; Myeloid leukemia; Cancer research; Myeloid; Biology; Fanconi anemia; Stem cell; Myelodysplastic syndromes; Leukemia; Molecular biology; Immunology; Genetics; Gene; DNA repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001107868,0.0001728261,0.0001348799,0.0004429897,0.0001222535,0.0002108698,0.0002136336,0.000257053,0.0006299378],"category_scores_gemma":[0.000103198,0.0001131418,0.0001051241,0.0001564355,0.0002636482,0.0001411426,0.0002215296,0.0002755144,0.0001502794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002192741,"about_ca_system_score_gemma":0.0001262027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007011473,"about_ca_topic_score_gemma":0.0006665737,"domain_scores_codex":[0.999928,0.00001724845,0.000006095685,0.00001243794,0.00002363301,0.00001264113],"domain_scores_gemma":[0.9999543,0.000007765012,0.000009491309,0.000008896791,0.000003472225,0.00001604439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004733406,0.0000500415,0.00229035,0.00003765591,0.00001205347,0.0003404599,0.00005792275,0.0007237524,0.9921297,0.00130175,0.0000970836,0.002485789],"study_design_scores_gemma":[0.0002141365,0.002639576,0.1659433,0.00004865351,0.0001124448,0.008737036,0.0005331569,0.01533884,0.7893752,0.004527008,0.01249738,0.00003311565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967199,0.0009756919,0.001212085,0.00004899913,0.00000580725,0.00001650647,0.0002407976,0.0000350357,0.0007451355],"genre_scores_gemma":[0.9981541,0.0004076483,0.0006165629,0.0000189093,0.000002409251,0.0000293434,0.0003162033,0.000005901271,0.000448953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007011473,"threshold_uncertainty_score":0.002107322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003086046407653976,"score_gpt":0.1736209400998564,"score_spread":0.1705348936922024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}