{"id":"W4241466402","doi":"10.1002/ange.201903500","title":"In vitro Reconstitution of the Biosynthetic Pathway to the Nitroimidazole Antibiotic Azomycin","year":2019,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Genome British Columbia; Michael Smith Health Research BC","keywords":"Actinobacteria; Gene cluster; Streptomyces; Nitroimidazole; Chemistry; Computational biology; Gene; Microbiology; Bacteria; Biochemistry; Biology; Genetics; 16S ribosomal RNA; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004102499,0.0005482077,0.0004093323,0.000242383,0.0001903489,0.0003819633,0.0004227049,0.000361842,0.001099708],"category_scores_gemma":[0.0002607332,0.0001864153,0.0003325738,0.000375091,0.0002163633,0.000201007,0.0004484438,0.0008665455,0.0007651235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004337237,"about_ca_system_score_gemma":0.0003140057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001254505,"about_ca_topic_score_gemma":0.001117098,"domain_scores_codex":[0.9996603,0.00009385842,0.00003845273,0.00005921474,0.00008857781,0.00005968753],"domain_scores_gemma":[0.999848,0.00003464224,0.00003382466,0.00003052919,0.00001900555,0.00003399981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005942573,0.00005398332,0.00008574942,0.00006099798,0.000007419476,0.00003936144,0.00002389319,0.0002807307,0.9981261,0.0003358628,0.00007716296,0.0008493898],"study_design_scores_gemma":[0.00001242615,0.0001819049,0.0005501623,0.00000961123,0.00001589087,0.00005868532,0.00002213333,0.002008902,0.9913266,0.000081045,0.005725289,0.000007434126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9590892,0.002502947,0.02899129,0.0003145565,0.0002457505,0.000169769,0.002891217,0.0004611499,0.005334335],"genre_scores_gemma":[0.9788452,0.001117965,0.01196803,0.00004597333,0.00001855529,0.00006500447,0.003615853,0.00009200836,0.004231462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001254505,"threshold_uncertainty_score":0.003678858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01104221419655724,"score_gpt":0.2227548833380356,"score_spread":0.2117126691414784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}