{"id":"W4241519036","doi":"10.1016/j.annonc.2020.01.049","title":"1O Inducible T cell co-stimulatory (ICOS) receptor agonist, GSK3359609 (GSK609) alone and combination with pembrolizumab: Preliminary results from INDUCE-1 expansion cohorts in head and neck squamous cell carcinoma (HNSCC)","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Pembrolizumab; Head and neck squamous-cell carcinoma; Internal medicine; Population; Tolerability; Agonist; Oncology; Head and neck cancer; Gastroenterology; Cancer; Receptor; Adverse effect; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004496188,0.0004651975,0.0005992519,0.0002483357,0.0002422922,0.0004906501,0.0002824105,0.0002623131,0.002106011],"category_scores_gemma":[0.0001960181,0.0001731863,0.0004833399,0.0001747487,0.0003599039,0.0003581514,0.0002271908,0.001179229,0.000431676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005091742,"about_ca_system_score_gemma":0.0007314832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001213708,"about_ca_topic_score_gemma":0.006465498,"domain_scores_codex":[0.9998392,0.00003878618,0.000006663543,0.00002525988,0.00002704795,0.00006296993],"domain_scores_gemma":[0.999895,0.00001930555,0.00001412777,0.00001445869,0.000007808617,0.00004917838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1361234,0.03695633,0.0294787,0.0007898206,0.0006667482,0.0003897721,0.0004223915,0.002957765,0.5403296,0.0002909722,0.006889411,0.2447051],"study_design_scores_gemma":[0.03945566,0.5322744,0.1922752,0.00008982253,0.001927376,0.001131832,0.0006272504,0.004450201,0.2152805,0.0003883949,0.01203236,0.00006710275],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975641,0.0008936027,0.0001040983,0.00008319131,0.00003201074,0.0001334743,0.0002767749,0.00003288707,0.0008799332],"genre_scores_gemma":[0.9954157,0.0009918956,0.0005131694,0.0001166528,0.00003466843,0.000190394,0.00101963,0.00001242127,0.001705582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002106011,"threshold_uncertainty_score":0.007045329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05711588904831182,"score_gpt":0.3158570011451614,"score_spread":0.2587411120968496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}