{"id":"W4241523791","doi":"10.1097/00054725-200812003-00095","title":"Quality of life improvements with Natalizumab induction therapy in patients exposed to or failing TNF-alpha inhibitor therapy in the ENCORE Trial","year":2008,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Calgary","funders":"","keywords":"Medicine; Internal medicine; Adverse effect; Natalizumab; Inflammatory bowel disease; Placebo; Gastroenterology; Quality of life (healthcare); Crohn's disease; Alpha (finance); Tumor necrosis factor alpha; Disease; Surgery; Pathology; Construct validity; Patient satisfaction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001274839,0.0004677062,0.001455452,0.0001147189,0.0001758567,0.0005665214,0.0002588863,0.0005026363,0.001383463],"category_scores_gemma":[0.00117904,0.0001516336,0.001054431,0.0001689194,0.0003103364,0.0003936191,0.0002874342,0.001136981,0.00009041643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002723867,"about_ca_system_score_gemma":0.0003071053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003169275,"about_ca_topic_score_gemma":0.001030287,"domain_scores_codex":[0.9993995,0.000333723,0.00005420184,0.0000715177,0.00005608074,0.00008486168],"domain_scores_gemma":[0.9993148,0.0001923795,0.0002436601,0.00004844533,0.00003118528,0.0001695602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9211892,0.00440298,0.02154735,0.0007547068,0.00271883,0.0001443439,0.0001212576,0.0005975903,0.004579316,0.0001051311,0.0008987674,0.04294043],"study_design_scores_gemma":[0.5079006,0.2424179,0.2381358,0.0001953043,0.004206499,0.0004679541,0.0001355386,0.001329701,0.002104616,0.0002159109,0.002840541,0.00004951735],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966504,0.002591694,0.00005287786,0.0000981076,0.0000354777,0.00007333533,0.0001213006,0.000006550541,0.0003702627],"genre_scores_gemma":[0.9975646,0.001042552,0.0001796662,0.0002031409,0.00008026364,0.0001618183,0.0003856878,0.000001655837,0.000380669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001455452,"threshold_uncertainty_score":0.00674206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02594671932018006,"score_gpt":0.2691748314745654,"score_spread":0.2432281121543854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}