{"id":"W4241649982","doi":"10.3410/f.730230409.793573479","title":"Faculty Opinions recommendation of The Chemical Chaperone, PBA, Reduces ER Stress and Autophagy and Increases Collagen IV α5 Expression in Cultured Fibroblasts From Men With X-Linked Alport Syndrome and Missense Mutations.","year":2020,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Research Councils UK; Kidney Foundation of Canada; Alport Syndrome Foundation; American Society of Nephrology","keywords":"Immunostaining; Phenylbutyrate; Unfolded protein response; Endoplasmic reticulum; Chemistry; Endocrinology; Molecular biology; Missense mutation; Internal medicine; Fibroblast; Biology; Biochemistry; Medicine; Phenotype; In vitro; Immunohistochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001250556,0.001195633,0.001410725,0.001938421,0.0005900914,0.001601173,0.001547228,0.001674308,0.02812671],"category_scores_gemma":[0.005935018,0.000379074,0.001627804,0.002567451,0.0002358894,0.0006365739,0.0009616493,0.001072941,0.01918641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001024,"about_ca_system_score_gemma":0.002034397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01716528,"about_ca_topic_score_gemma":0.04498313,"domain_scores_codex":[0.9990742,0.0002110454,0.0001362865,0.0002690353,0.0002092212,0.0001001753],"domain_scores_gemma":[0.997876,0.0007504603,0.0004325119,0.0002777397,0.000455386,0.0002078261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001122347,0.0001125146,0.01143643,0.007633089,0.0007794253,0.000105472,0.0000528312,0.0006658676,0.001466113,0.0003360709,0.9615302,0.01475965],"study_design_scores_gemma":[0.002982172,0.0002577193,0.06018727,0.001892063,0.001382398,0.0004249316,0.0001435683,0.001292878,0.002647588,0.0009057102,0.927794,0.0000897328],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.001447814,0.0007661337,0.00004723676,0.0002435143,0.00003783062,0.00002126798,0.9965066,0.0001261626,0.000803393],"genre_scores_gemma":[0.002515555,0.0003863305,0.0002878964,0.0001348121,0.00001221801,0.00007659806,0.9958348,0.0000228473,0.0007289327],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.02812671,"threshold_uncertainty_score":0.09409326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02224831489598438,"score_gpt":0.3260489137467107,"score_spread":0.3038005988507263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}