{"id":"W4241829898","doi":"10.1161/circ.131.suppl_2.o21","title":"Abstract O.21: Inositol 1,4,5 triphosphate 3- kinase C regulates NLRP3 Inflammasome activation in Kawasaki disease","year":2015,"lang":"en","type":"article","venue":"Circulation","topic":"Kawasaki Disease and Coronary Complications","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Inflammasome; Molecular biology; Western blot; Interleukin 18; Receptor; Cytokine; Medicine; Gene expression; Gene; Immunology; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000107661,0.000399002,0.0003472283,0.0002648949,0.0002542218,0.0003361152,0.000187992,0.0003656254,0.004179913],"category_scores_gemma":[0.0001750503,0.0001039774,0.0001867644,0.0002687097,0.000231559,0.0001647783,0.0002647679,0.0004716894,0.001214358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003990691,"about_ca_system_score_gemma":0.0002253564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007226814,"about_ca_topic_score_gemma":0.0005712487,"domain_scores_codex":[0.9999026,0.00001470657,0.000009052161,0.00003016112,0.00002046998,0.00002292007],"domain_scores_gemma":[0.9999131,0.00000722715,0.00003410853,0.000005508559,0.00001330851,0.00002668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002589192,0.0001194546,0.007722253,0.0003494337,0.00003011357,0.001445761,0.0001129927,0.0001787393,0.9742219,0.000159613,0.002777161,0.01029349],"study_design_scores_gemma":[0.0004976976,0.001139434,0.6986198,0.0002038138,0.0002006266,0.008412056,0.000529244,0.002464702,0.2669674,0.0006403262,0.02028585,0.00003913497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862266,0.006062525,0.001241557,0.0006985823,0.0001470711,0.00005415642,0.001777011,0.0001921508,0.003600331],"genre_scores_gemma":[0.9909525,0.002147971,0.001280252,0.000245916,0.00008907984,0.00009931908,0.001344512,0.00004530801,0.003795176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004179913,"threshold_uncertainty_score":0.01398325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0365637462399936,"score_gpt":0.2840643698371003,"score_spread":0.2475006235971067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}