{"id":"W4241991240","doi":"10.1161/circ.116.suppl_16.ii_34-a","title":"Abstract 270: Insulin-Like Growth Factor-1 Promotes Vascular Smooth Muscle Survival By 26S Proteasome-Mediated Degradation of Wilms’ Tumor 1-Associating Protein","year":2007,"lang":"en","type":"article","venue":"Circulation","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials","funders":"","keywords":"Cell biology; Downregulation and upregulation; Insulin-like growth factor; Biology; Lactacystin; Cancer research; Medicine; Endocrinology; Proteasome; Molecular biology; Internal medicine; Growth factor; Proteasome inhibitor; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002138192,0.001308918,0.0004870621,0.0003059233,0.0002968982,0.0005631062,0.0003576054,0.0003672474,0.007872024],"category_scores_gemma":[0.0001648808,0.0002302774,0.0003962972,0.0002493951,0.0002815561,0.0003843866,0.0003278258,0.0009223295,0.003516488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000760318,"about_ca_system_score_gemma":0.0003967122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006252021,"about_ca_topic_score_gemma":0.0006566866,"domain_scores_codex":[0.9997801,0.00002456163,0.00002117199,0.00006009923,0.00006110728,0.00005283056],"domain_scores_gemma":[0.9998575,0.00001624021,0.00004059408,0.00001383604,0.00002378312,0.00004790154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006826937,0.00009112909,0.000110359,0.0001418869,0.00001398827,0.0001997236,0.000008755634,0.00005042576,0.9966353,0.0001335107,0.0004146247,0.00151768],"study_design_scores_gemma":[0.0002274523,0.0008243317,0.01202091,0.00003718294,0.00003774562,0.001105689,0.00004726453,0.00161446,0.970144,0.0002202135,0.01370324,0.00001763807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9566724,0.01738971,0.005980465,0.001463823,0.0009756186,0.0001551544,0.005405191,0.0005907479,0.01136691],"genre_scores_gemma":[0.940248,0.008797835,0.006146056,0.000532207,0.000404426,0.0001674189,0.01098366,0.0001375099,0.03258294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007872024,"threshold_uncertainty_score":0.02633452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0130413697072856,"score_gpt":0.2366028546405018,"score_spread":0.2235614849332162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}