{"id":"W4242346422","doi":"10.21203/rs.3.rs-121986/v1","title":"Germline Determinants of Humoral Immune Response To HPV-16 Protect Against Oropharyngeal Cancer","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College; Ontario Institute for Cancer Research; Lunenfeld-Tanenbaum Research Institute","funders":"National Institute of Dental and Craniofacial Research; Canadian Cancer Society Research Institute; National Institutes of Health; University of Pittsburgh; Cancer Care Ontario; European Commission; Centre International de Recherche sur le Cancer; Princess Margaret Hospital Foundation","keywords":"Germline; Cancer; Immune system; Medicine; Immunology; Biology; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000242286,0.0001902371,0.0001563057,0.0002085351,0.00008405702,0.0003397473,0.0001212006,0.0002556077,0.005878853],"category_scores_gemma":[0.0006382993,0.0001060987,0.0001348214,0.00008610996,0.000143992,0.0001629794,0.0002162678,0.0004511767,0.0007406726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001312456,"about_ca_system_score_gemma":0.0001523318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003491679,"about_ca_topic_score_gemma":0.0002641512,"domain_scores_codex":[0.999863,0.00003927213,0.000004421925,0.00001749398,0.00002327995,0.00005252321],"domain_scores_gemma":[0.9997212,0.00008087083,0.00005782615,0.00004636657,0.00003194273,0.00006172567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004627574,0.001392084,0.072802,0.0001554218,0.000140496,0.000245125,0.0001256355,0.0007691359,0.8600269,0.001957145,0.002290291,0.05546826],"study_design_scores_gemma":[0.0008785165,0.007952093,0.6714596,0.0001331427,0.0003394346,0.001576653,0.0004540902,0.00383063,0.2872674,0.004170177,0.02191274,0.00002555779],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945427,0.0004887704,0.0003563428,0.0001738986,0.00005335987,0.00001098015,0.000154969,0.00003279625,0.004186078],"genre_scores_gemma":[0.996558,0.0002338212,0.0001866736,0.00009986147,0.00005187943,0.000007536461,0.0001328331,0.00001520756,0.002714231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005878853,"threshold_uncertainty_score":0.01966679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1371978905560793,"score_gpt":0.483177876088495,"score_spread":0.3459799855324157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}