{"id":"W4242403585","doi":"10.3410/f.737316694.793572169","title":"Faculty Opinions recommendation of Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors.","year":2020,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute of Neurological Disorders and Stroke; Japan Society for the Promotion of Science; National Institute of Child Health and Human Development; Natural Sciences and Engineering Research Council of Canada; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University of British Columbia; National Natural Science Foundation of China; National Institute of Mental Health; Fudan University; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Max-Planck-Gesellschaft; Deutsche Forschungsgemeinschaft; Simons Foundation Autism Research Initiative; Howard Hughes Medical Institute; Ministry of Education, Culture, Sports, Science and Technology; Canadian Institutes of Health Research; National Science Foundation","keywords":"Germline; Recombinase; Biology; Genetics; Recombination; Cre recombinase; Locus (genetics); Homologous recombination; FLP-FRT recombination; Gene; Genetic recombination; Transgene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003828706,0.001579657,0.001708204,0.007570668,0.00077168,0.003767595,0.002128696,0.001258944,0.1463598],"category_scores_gemma":[0.02939946,0.0006536875,0.001383438,0.01366934,0.0003043535,0.002384872,0.002768089,0.001541465,0.1243354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001674662,"about_ca_system_score_gemma":0.004305338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01134879,"about_ca_topic_score_gemma":0.03403765,"domain_scores_codex":[0.9961577,0.0008035832,0.0006389319,0.0008135264,0.001303549,0.0002828464],"domain_scores_gemma":[0.980911,0.006921925,0.002400261,0.002369606,0.005699399,0.001697787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001109338,0.00001709775,0.00304536,0.004008417,0.0001368151,0.00002636796,0.00006092988,0.000188262,0.0004407491,0.0005870742,0.9780794,0.01329845],"study_design_scores_gemma":[0.00008171405,0.00001103138,0.004779072,0.0009180812,0.00008982146,0.00003574312,0.00006099148,0.0001529256,0.0006772612,0.0005910897,0.9925752,0.00002722653],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.000183257,0.0002188832,0.0002128746,0.0001881161,0.00003460497,0.00002584576,0.996052,0.0007018316,0.002382656],"genre_scores_gemma":[0.0008856255,0.000385699,0.001223049,0.0001980435,0.0000172522,0.0002029196,0.9948638,0.0004296796,0.001793919],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.1463598,"threshold_uncertainty_score":0.4896222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01579181471023446,"score_gpt":0.3140925013665546,"score_spread":0.2983006866563202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}