{"id":"W4242413941","doi":"10.1002/mc.20107","title":"Targeting NAD(P)H:quinone oxidoreductase (NQO1) in pancreatic cancer","year":2005,"lang":"en","type":"article","venue":"Molecular Carcinogenesis","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; National Cancer Institute; Foundation of Hope for Research and Treatment of Mental Illness; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Pancreatic cancer; Biology; Clonogenic assay; Cancer research; NAD+ kinase; Pancreatic Intraepithelial Neoplasia; Pancreas; Cancer; Cell culture; Cancer cell; Molecular biology; Cell; Endocrinology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003658565,0.0002988826,0.0003486493,0.0001853527,0.0001724284,0.00002412787,0.0002870108,0.0002221528,0.001121361],"category_scores_gemma":[0.00004232959,0.0003044191,0.0001462927,0.0003884671,0.0001341554,0.0001036191,0.0001075399,0.0003716556,0.00009976658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002045982,"about_ca_system_score_gemma":0.0001031488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003432782,"about_ca_topic_score_gemma":0.00008018214,"domain_scores_codex":[0.9979153,0.0003673702,0.0003847846,0.0004794666,0.0002034949,0.0006495862],"domain_scores_gemma":[0.9992975,0.00006246459,0.0001086101,0.0002237037,0.00008017138,0.0002275625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001299833,0.0003227688,0.1276726,0.0000493115,0.0001746673,0.0003739832,0.0003020843,0.004605837,0.8557304,0.0001912203,0.00183252,0.008614615],"study_design_scores_gemma":[0.002561729,0.00007781033,0.03813048,0.00004864243,0.0003784728,0.00003619282,0.0002260235,0.007470986,0.8757222,0.00008749215,0.07446,0.0007999543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835325,0.01279938,0.0002630925,0.001300104,0.0004590194,0.000329787,0.00006208184,0.00006294697,0.001191059],"genre_scores_gemma":[0.9951037,0.0008753057,0.0007547977,0.002417756,0.0003142633,0.0001272066,0.0000382099,0.00004755293,0.0003211901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08954215,"threshold_uncertainty_score":0.9999408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07324748171060018,"score_gpt":0.395115716120495,"score_spread":0.3218682344098948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}