{"id":"W4242438297","doi":"10.1007/978-3-319-48066-4_14","title":"Talimogene Laherparepvec","year":2016,"lang":"de","type":"book-chapter","venue":"","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Oncolytic virus; Medicine; Melanoma; Herpes simplex virus; Immunotherapy; Tumor cells; Clinical trial; Cancer research; Virus; Virology; Immunology; Internal medicine; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003067936,0.0009170037,0.0005530124,0.001533694,0.0004156703,0.001412016,0.0008984001,0.0009174437,0.0754263],"category_scores_gemma":[0.0003068744,0.0003974607,0.0003808498,0.000631467,0.0003634683,0.001200092,0.0007765083,0.002110489,0.06508766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004882728,"about_ca_system_score_gemma":0.0004658479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003635339,"about_ca_topic_score_gemma":0.000816514,"domain_scores_codex":[0.999787,0.00001367432,0.000006722497,0.00004891251,0.0001210331,0.00002258065],"domain_scores_gemma":[0.9999175,0.00002297243,0.00001152235,0.00001492024,0.00001418721,0.00001885682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002058689,0.0001037837,0.0001115094,0.0005870581,0.00002149521,0.0002477014,0.0001273167,0.0003096043,0.1248943,0.04704433,0.1919902,0.6343567],"study_design_scores_gemma":[0.00001724191,0.00004283503,0.0001327641,0.00006436815,0.00001457229,0.0004780498,0.000009659298,0.0002017063,0.0276992,0.002503289,0.9688274,0.000008921522],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.007615712,0.05563034,0.08238608,0.002774777,0.002597403,0.0002212066,0.003749449,0.0112066,0.8338184],"genre_scores_gemma":[0.01975831,0.0227692,0.02021568,0.001409662,0.0003060465,0.0003563824,0.003757484,0.001346286,0.930081],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.0754263,"threshold_uncertainty_score":0.2523261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02283923687394519,"score_gpt":0.2875219445581715,"score_spread":0.2646827076842263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}