{"id":"W4242542620","doi":"10.1523/jneurosci.1008-14.2014","title":"PKA Reduces the Rat and Human KCa3.1 Current, CaM Binding, and Ca<sup>2+</sup>Signaling, Which Requires Ser332/334 in the CaM-Binding C Terminus","year":2014,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Heart and Stroke Foundation of Canada","keywords":"Microglia; Calmodulin; Protein kinase A; HEK 293 cells; Cell biology; Kinase; Phosphorylation; Chemistry; Mutant; Gating; Signal transduction; Biology; Molecular biology; Biophysics; Receptor; Biochemistry; Enzyme; Gene; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001920718,0.0005101472,0.0004262225,0.0001823605,0.000172562,0.0003082708,0.0002470528,0.0004424861,0.00358686],"category_scores_gemma":[0.0002852431,0.0002113317,0.0005669013,0.0001286213,0.0004376796,0.0002830029,0.0001598845,0.001026733,0.0007914263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004078189,"about_ca_system_score_gemma":0.0004633984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001651774,"about_ca_topic_score_gemma":0.00153753,"domain_scores_codex":[0.999744,0.00003012346,0.00003125946,0.00004775771,0.00005749379,0.00008947554],"domain_scores_gemma":[0.9998641,0.00002249517,0.0000271402,0.00002130157,0.00001535955,0.00004953472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006199711,0.0001201182,0.00009277354,0.00006028047,0.00001260358,0.00005437604,0.00001568643,0.0000543126,0.9968663,0.0001100746,0.0002410426,0.001752441],"study_design_scores_gemma":[0.00008648309,0.0007612004,0.004215326,0.000006275608,0.00002918469,0.000354106,0.00003023842,0.0006660645,0.9905366,0.00006968875,0.003237599,0.000007296611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890808,0.003928839,0.001843696,0.0006968657,0.0002674861,0.00007358036,0.00113216,0.0002335328,0.002742948],"genre_scores_gemma":[0.9880172,0.002191709,0.001975584,0.0003081336,0.00006912946,0.000101538,0.001313824,0.00007443683,0.005948379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00358686,"threshold_uncertainty_score":0.01199925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02726042854930663,"score_gpt":0.2940146980209294,"score_spread":0.2667542694716227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}