{"id":"W4242542620","doi":"10.1523/jneurosci.1008-14.2014","title":"PKA Reduces the Rat and Human KCa3.1 Current, CaM Binding, and Ca<sup>2+</sup>Signaling, Which Requires Ser332/334 in the CaM-Binding C Terminus","year":2014,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Heart and Stroke Foundation of Canada","keywords":"Microglia; Calmodulin; Protein kinase A; HEK 293 cells; Cell biology; Kinase; Phosphorylation; Chemistry; Mutant; Gating; Signal transduction; Biology; Molecular biology; Biophysics; Receptor; Biochemistry; Enzyme; Gene; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009388875,0.0001108113,0.0001109092,0.00009508475,0.0003480251,0.0001555597,0.0002619431,0.00005247817,0.000002469115],"category_scores_gemma":[0.0003086815,0.00006480124,0.00003690625,0.0001978209,0.0001847122,0.0000315785,0.00006866859,0.0002015597,5.217011e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009065131,"about_ca_system_score_gemma":0.00004177307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005222423,"about_ca_topic_score_gemma":0.000006602171,"domain_scores_codex":[0.9989164,0.0001876079,0.000265692,0.0002115795,0.0002408326,0.0001778157],"domain_scores_gemma":[0.9994467,0.00003798514,0.0002373082,0.0001361293,0.00007921449,0.00006258544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002905105,0.00003707215,0.004690699,0.00001301424,0.000002523971,0.000004629448,0.0008276536,0.0007030335,0.9894215,0.00005165229,0.002112297,0.002106901],"study_design_scores_gemma":[0.004651363,0.004986215,0.06106097,0.0006041374,0.0001485793,0.00630156,0.006287328,0.03895023,0.5224519,0.0006662561,0.3525124,0.001379063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980944,0.0002135711,0.0000995575,0.0008503397,0.0005601716,0.0000830871,0.000001930734,0.000002203227,0.00009467531],"genre_scores_gemma":[0.998884,0.0001799782,0.00001295896,0.000291435,0.0004363098,0.000002192219,0.000001994079,0.000006576809,0.0001846135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4669695,"threshold_uncertainty_score":0.2676763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02726042854930663,"score_gpt":0.2940146980209294,"score_spread":0.2667542694716227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}