{"id":"W4242642991","doi":"10.21203/rs.3.rs-29102/v1","title":"Induction of autophagy mitigates TDP-43 pathology and translational repression of neurofilament mRNAs in mouse models of ALS/FTD","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Fondation Brain Canada; ALS Society of Canada","keywords":"Autophagy; Tau pathology; Cell biology; Psychological repression; Neurofilament; Neuroscience; Biology; Pathology; Medicine; Genetics; Immunohistochemistry; Gene expression; Gene; Disease; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002832648,0.001039884,0.0008238367,0.0009272153,0.000342055,0.0003966537,0.0004637393,0.0007028154,0.001015961],"category_scores_gemma":[0.000106982,0.0003030988,0.0005759515,0.0002718268,0.000539761,0.0003640144,0.0002293724,0.00131108,0.0003261605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006007768,"about_ca_system_score_gemma":0.0004049433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008365828,"about_ca_topic_score_gemma":0.001981683,"domain_scores_codex":[0.9997429,0.00003045158,0.00003983093,0.00006112185,0.00006337,0.00006229273],"domain_scores_gemma":[0.9997719,0.00001234237,0.00008358122,0.00002035429,0.0000229707,0.00008886914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006754978,0.0003362743,0.0001477656,0.00006306764,0.0000168566,0.00005522903,0.00002196532,0.00006621557,0.9975636,0.00005695969,0.00007015657,0.0009265097],"study_design_scores_gemma":[0.0001367399,0.004048929,0.002995711,0.00001662986,0.00006500749,0.0002524292,0.00004640354,0.0008730316,0.9900159,0.00006650176,0.001471065,0.00001151074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959247,0.0008413374,0.001327602,0.0001423655,0.00006076468,0.00008269255,0.0006126676,0.0002664251,0.0007413951],"genre_scores_gemma":[0.9907459,0.0009126781,0.003194594,0.0001069308,0.0000248557,0.0002333965,0.0009761879,0.00005491962,0.003750637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001039884,"threshold_uncertainty_score":0.004358888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1460262810088069,"score_gpt":0.4098666216877116,"score_spread":0.2638403406789047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}