{"id":"W4242650650","doi":"10.1158/1538-7445.sabcs18-p6-17-13","title":"Abstract P6-17-13: ZW49, a HER2 targeted biparatopic antibody drug conjugate for the treatment of HER2 expressing cancers","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Trastuzumab; Antibody-drug conjugate; Medicine; In vivo; Tolerability; Pertuzumab; Cancer; Breast cancer; Cancer research; Pharmacology; Lapatinib; Internalization; Antibody; Internal medicine; Monoclonal antibody; Immunology; Adverse effect; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001341598,0.0003661032,0.0001640959,0.0003042464,0.0000936887,0.0002061155,0.0002718831,0.0003203392,0.00479694],"category_scores_gemma":[0.00008671744,0.00009662619,0.0001762173,0.0001515859,0.0001073258,0.0002239959,0.0002171654,0.0003985271,0.00143592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002217299,"about_ca_system_score_gemma":0.0002235203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003769583,"about_ca_topic_score_gemma":0.0002699907,"domain_scores_codex":[0.9999461,0.000008644221,0.000003704982,0.00000827528,0.00002061208,0.00001263201],"domain_scores_gemma":[0.999961,0.000003697712,0.0000107979,0.000002483009,0.000009423619,0.00001259273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007654294,0.0003146893,0.0003405157,0.0001847102,0.00002955918,0.0003605031,0.00001815789,0.0007804157,0.9641252,0.000529583,0.002044898,0.03050642],"study_design_scores_gemma":[0.0004285134,0.004967321,0.002489346,0.00002517483,0.00004318686,0.001552496,0.00001419861,0.001909233,0.9645953,0.0001421494,0.02382167,0.00001138729],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9510779,0.008517588,0.0142747,0.0006065767,0.000229624,0.0007777209,0.001963493,0.0004168413,0.02213557],"genre_scores_gemma":[0.9661918,0.004788281,0.006753827,0.0002335036,0.00005710379,0.000204402,0.002118975,0.00007453202,0.01957745],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.00479694,"threshold_uncertainty_score":0.01604742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08880423222923725,"score_gpt":0.4473058347096451,"score_spread":0.3585016024804079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}