{"id":"W4242650650","doi":"10.1158/1538-7445.sabcs18-p6-17-13","title":"Abstract P6-17-13: ZW49, a HER2 targeted biparatopic antibody drug conjugate for the treatment of HER2 expressing cancers","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Trastuzumab; Antibody-drug conjugate; Medicine; In vivo; Tolerability; Pertuzumab; Cancer; Breast cancer; Cancer research; Pharmacology; Lapatinib; Internalization; Antibody; Internal medicine; Monoclonal antibody; Immunology; Adverse effect; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006665313,0.0002378549,0.0005373458,0.0002011842,0.0003122289,0.00006048701,0.0003367155,0.0000974583,0.001954528],"category_scores_gemma":[0.00005264766,0.0001430479,0.0002546535,0.0004340002,0.0004773137,0.00009424908,0.00007156812,0.0003990602,0.0000873836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005323974,"about_ca_system_score_gemma":0.001193643,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01959975,"about_ca_topic_score_gemma":0.0009063812,"domain_scores_codex":[0.9970904,0.0001071836,0.0003853655,0.0004945431,0.0009988394,0.0009236561],"domain_scores_gemma":[0.9975575,0.000918766,0.00009469024,0.0005901738,0.0005806152,0.0002583049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00748516,0.0007778757,0.06771493,0.001953058,0.001208221,0.00008448184,0.004811129,0.0005260727,0.8333936,0.0002951172,0.03407213,0.04767823],"study_design_scores_gemma":[0.005945486,0.002109358,0.08835337,0.0008906936,0.00009407084,0.00001143417,0.001527067,0.001979858,0.3199246,0.0001825402,0.5786129,0.0003686534],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726087,0.01762498,0.000009180554,0.004040254,0.0002934549,0.002326512,0.0001971817,0.00002464884,0.002875082],"genre_scores_gemma":[0.9544173,0.009090749,0.00008290729,0.000146618,0.0005766787,0.0005341404,0.00006828408,0.00004693398,0.03503637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5445408,"threshold_uncertainty_score":0.9989578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08880423222923725,"score_gpt":0.4473058347096451,"score_spread":0.3585016024804079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}