{"id":"W4242667205","doi":"10.3410/f.719106238.793503078","title":"Faculty Opinions recommendation of GSK256066, an exceptionally high-affinity and selective inhibitor of phosphodiesterase 4 suitable for administration by inhalation: in vitro, kinetic, and in vivo characterization.","year":2015,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"In vivo; Phosphodiesterase; Pharmacology; In vitro; Inhalation; cGMP-specific phosphodiesterase type 5; Chemistry; Medicine; Enzyme; Biochemistry; Internal medicine; Biology; Biotechnology; Anesthesia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009209806,0.0003007691,0.0005370725,0.0002123144,0.00008880228,0.00006101024,0.0002426044,0.0005526791,0.00002699287],"category_scores_gemma":[0.001705392,0.0002395713,0.000101348,0.0006136145,0.0002316382,0.00009535142,0.0001383926,0.0002604953,3.766037e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005919522,"about_ca_system_score_gemma":0.0004299138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005520302,"about_ca_topic_score_gemma":0.00005892233,"domain_scores_codex":[0.9975113,0.0002920737,0.001088342,0.0005032162,0.0004300291,0.0001750623],"domain_scores_gemma":[0.9957714,0.00005675775,0.0009697634,0.0004074373,0.002655921,0.0001387064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002998375,0.0004678617,0.00008946683,0.001982722,0.00004156134,5.298445e-8,0.000113822,7.328866e-7,0.006013411,0.00002998005,0.9902274,0.0007331376],"study_design_scores_gemma":[0.001507718,0.0004089525,0.009302808,0.001359564,0.00005169163,0.00001082291,0.00003109739,0.00003540068,0.008965867,0.00002147566,0.9780682,0.0002364003],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.002087434,0.0004597364,0.0001126337,0.01060581,0.0002824613,0.001289472,0.9851521,0.000005904776,0.000004397441],"genre_scores_gemma":[0.00515598,0.0002659429,0.0005147711,0.0005157807,0.0001277323,0.0002241628,0.9929634,0.00001586744,0.0002163044],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.01215921,"threshold_uncertainty_score":0.9769433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01767095327513354,"score_gpt":0.3124990982229031,"score_spread":0.2948281449477695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}