{"id":"W4242882541","doi":"10.21203/rs.2.21846/v1","title":"Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Diet and metabolism studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; European Regional Development Fund; Instituto de Salud Carlos III; National Institutes of Health; Genentech; IXICO; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Fundació la Marató de TV3; Novartis Pharmaceuticals Corporation; Biogen; BioClinica; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; F. Hoffmann-La Roche; University of Southern California; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Obesity; Amyloid (mycology); Medicine; Metabolism; Amyloid β; Neuroscience; Pathology; Gerontology; Psychology; Endocrinology; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001574247,0.0003324505,0.001387711,0.0006704866,0.0001016979,0.00005126798,0.0002227286,0.000555424,0.00004019964],"category_scores_gemma":[0.00180758,0.0002774647,0.00009771401,0.0004159797,0.000468359,0.00006487168,0.001726114,0.002665953,0.000002426705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000672321,"about_ca_system_score_gemma":0.0006183572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000960599,"about_ca_topic_score_gemma":0.0007494905,"domain_scores_codex":[0.9962762,0.0006655735,0.0004971814,0.0008037942,0.001043448,0.0007138132],"domain_scores_gemma":[0.9981265,0.0003404222,0.0001507399,0.0004805861,0.0003971947,0.0005045288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006087941,0.0008405153,0.8475854,0.02607765,0.0006952245,0.001737136,0.0322538,0.000004491736,0.02491122,0.003919002,0.006737768,0.04914986],"study_design_scores_gemma":[0.002645044,0.00085932,0.9849216,0.0005630159,0.00005475056,0.00003050441,0.001434666,0.000009689868,0.00042746,0.006586331,0.002274885,0.000192741],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9558104,0.03355678,0.000004997419,0.008411417,0.0001823976,0.001427068,0.0002876619,0.00002711927,0.0002921388],"genre_scores_gemma":[0.9846658,0.01418912,0.0003057907,0.00031668,0.0002908942,0.00004202061,0.00008032928,0.00003771151,0.00007168611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1373362,"threshold_uncertainty_score":0.9999678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05101598584151051,"score_gpt":0.3938981309815455,"score_spread":0.342882145140035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}