{"id":"W4242882541","doi":"10.21203/rs.2.21846/v1","title":"Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Diet and metabolism studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; European Regional Development Fund; Instituto de Salud Carlos III; National Institutes of Health; Genentech; IXICO; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Fundació la Marató de TV3; Novartis Pharmaceuticals Corporation; Biogen; BioClinica; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; F. Hoffmann-La Roche; University of Southern California; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Obesity; Amyloid (mycology); Medicine; Metabolism; Amyloid β; Neuroscience; Pathology; Gerontology; Psychology; Endocrinology; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003285689,0.0003210583,0.0002481276,0.0004249371,0.0001911406,0.0003966569,0.0001154625,0.000247653,0.001067427],"category_scores_gemma":[0.0007575142,0.0001933676,0.0002607691,0.0002640865,0.0002187723,0.0002198003,0.0002380727,0.0001667916,0.0001780175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008564931,"about_ca_system_score_gemma":0.00008996791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001387391,"about_ca_topic_score_gemma":0.001818068,"domain_scores_codex":[0.9998957,0.00002865858,0.00001226713,0.00002647434,0.00001671259,0.00002022563],"domain_scores_gemma":[0.999698,0.00005746511,0.0001221567,0.00003118585,0.00003099821,0.00006021132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001912496,0.000109231,0.9873882,0.00002711619,0.0002374574,0.0002161447,0.0001103992,0.00009894391,0.006736728,0.00002433649,0.00009520553,0.003043792],"study_design_scores_gemma":[0.000004412527,0.0001197808,0.9993997,0.000001719299,0.00003358813,0.0001102246,0.00002307994,0.00009434695,0.0001600856,0.00002105683,0.00003061256,0.000001327232],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996779,0.0001131965,0.00004694053,0.000006085896,0.000001573489,0.000001649465,0.00007090345,0.000001138785,0.00008070899],"genre_scores_gemma":[0.9996685,0.00005650254,0.00006732282,0.00001098418,0.000004203101,0.000002908569,0.00009427149,0.000001232348,0.00009416026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001387391,"threshold_uncertainty_score":0.003570914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05101598584151051,"score_gpt":0.3938981309815455,"score_spread":0.342882145140035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}