{"id":"W4242927800","doi":"10.21203/rs.3.rs-58082/v1","title":"Disrupted Mitochondrial and Metabolic Plasticity Underlie Comorbidity Between Age-related and Degenerative Disorders as Parkinson Disease and Type 2 Diabetes Mellitus","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Movement Disorders","funders":"Instituto de Salud Carlos III; Universitat de Barcelona; Generalitat de Catalunya; Fundación Cellex; Ministerio de Ciencia, Innovación y Universidades; Centres de Recerca de Catalunya","keywords":"Internal medicine; Comorbidity; Mitochondrion; Diabetes mellitus; Endocrinology; Biology; Oxidative stress; Carbohydrate metabolism; Type 2 diabetes; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003351069,0.0002354111,0.0003653893,0.000349669,0.000157158,0.0008572698,0.0001474958,0.0003951787,0.002565151],"category_scores_gemma":[0.001160949,0.0001044158,0.0001912454,0.0004126455,0.0002637181,0.0004115528,0.0004663844,0.0004035939,0.0002910108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002663702,"about_ca_system_score_gemma":0.0002951664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001368044,"about_ca_topic_score_gemma":0.001784953,"domain_scores_codex":[0.9998903,0.00002419656,0.000009360507,0.0000287875,0.00002520838,0.00002213337],"domain_scores_gemma":[0.999689,0.00006934634,0.0001263047,0.0000328644,0.000039222,0.00004330323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007730884,0.0005938615,0.4883768,0.0009687336,0.001399007,0.01008775,0.001389012,0.003773005,0.238861,0.03377996,0.01324868,0.1997912],"study_design_scores_gemma":[0.0001147978,0.0002718799,0.929879,0.00009895827,0.0003317275,0.005875953,0.0007511198,0.004936115,0.01437396,0.03598376,0.007350613,0.00003220447],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980711,0.007278262,0.002706757,0.002025578,0.0002162789,0.00001610755,0.001135887,0.00006678995,0.005843351],"genre_scores_gemma":[0.9945205,0.002355991,0.0007609266,0.0001208726,0.0001006336,0.000008169033,0.0004428049,0.00001026994,0.001679899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002565151,"threshold_uncertainty_score":0.008581281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0618236618026175,"score_gpt":0.3601733010515652,"score_spread":0.2983496392489477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}