{"id":"W4242982914","doi":"10.1093/annonc/mdv341.13","title":"Era 223-A Phase 3 Trial of Radium-223 Dichloride (Ra-223) in Combination with Abiraterone Acetate (Aa) and prednisone in the treatment of asymptomatic or mildly symptomatic chemotherapynaïve patients with bone-predominant metastatic Castration Resistant Prostate Cancer (Crpc)","year":2015,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Medicine; Abiraterone acetate; Internal medicine; Denosumab; Prednisone; Clinical endpoint; Chemotherapy regimen; Placebo; Interim analysis; Progression-free survival; Asymptomatic; Gastroenterology; Prostate cancer; Surgery; Urology; Chemotherapy; Randomized controlled trial; Cancer; Osteoporosis; Androgen deprivation therapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001107529,0.001239941,0.002181523,0.0004420174,0.0004261688,0.001342798,0.0008176913,0.001203094,0.003787357],"category_scores_gemma":[0.0007499558,0.0006409569,0.001947719,0.0004377484,0.0009282606,0.0006132222,0.0003557722,0.003438677,0.001207765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006441585,"about_ca_system_score_gemma":0.00138741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001633093,"about_ca_topic_score_gemma":0.005271936,"domain_scores_codex":[0.99967,0.000160456,0.00001551034,0.00004336018,0.00003062634,0.0000800605],"domain_scores_gemma":[0.9995697,0.00008291623,0.00007846287,0.00003676355,0.00002300973,0.0002091589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7518378,0.02899477,0.00421443,0.001335901,0.00323133,0.0004428853,0.0003605371,0.003714948,0.03783897,0.0006951794,0.008356669,0.1589766],"study_design_scores_gemma":[0.7062697,0.2697641,0.01087832,0.00008365494,0.001404874,0.0006303422,0.00008248407,0.001413004,0.003060729,0.0004643153,0.005895062,0.00005345651],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829795,0.006687214,0.0006138807,0.001052685,0.0003609462,0.001604776,0.001320939,0.0003787398,0.005001442],"genre_scores_gemma":[0.9811017,0.005096049,0.002083025,0.001830822,0.0003335358,0.001215002,0.002665592,0.0001007708,0.00557347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003787357,"threshold_uncertainty_score":0.01266998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08184937363807175,"score_gpt":0.4047958151610965,"score_spread":0.3229464415230248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}