{"id":"W4243113348","doi":"10.1200/jco.2017.35.15_suppl.502","title":"Updated results from the phase III ALTTO trial (BIG 2-06; NCCTG (Alliance) N063D) comparing one year of anti-HER2 therapy with lapatinib alone (L), trastuzumab alone (T), their sequence (T→L) or their combination (L+T) in the adjuvant treatment of HER2-positive early breast cancer.","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Lapatinib; Trastuzumab; Internal medicine; Tolerability; Clinical endpoint; Gastroenterology; Surgery; Breast cancer; Clinical trial; Cancer; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005112974,0.0003259769,0.00282913,0.0000927857,0.0001837795,0.00004590044,0.0009707257,0.0003355253,0.00009150694],"category_scores_gemma":[0.0009078152,0.0001460593,0.0003867447,0.0002783359,0.001261708,0.0001910167,0.00006976386,0.001206338,0.000003293533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005116839,"about_ca_system_score_gemma":0.00342763,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009266893,"about_ca_topic_score_gemma":0.00537571,"domain_scores_codex":[0.9933056,0.001822568,0.003038807,0.0004187601,0.0009801674,0.0004341466],"domain_scores_gemma":[0.9888585,0.004729877,0.004244,0.0009252595,0.001010773,0.0002315853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6356883,0.01992682,0.05029601,0.00002416246,0.002036168,0.0004381153,0.00867768,0.00005742271,0.003037671,0.0000290278,0.0005701836,0.2792184],"study_design_scores_gemma":[0.3224868,0.06103348,0.607914,0.0009613779,0.0002977558,0.00009002911,0.001507885,0.0003119498,0.003661978,0.0001033988,0.001464974,0.0001664296],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802098,0.0005650212,0.00002875353,0.01605629,0.0004529611,0.001789528,0.0005192509,0.00000796138,0.0003704723],"genre_scores_gemma":[0.991173,0.006924104,0.0002781461,0.0003461262,0.001088054,0.00004246767,0.00005492319,0.00003624645,0.00005688866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.557618,"threshold_uncertainty_score":0.9973305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3334326856360255,"score_gpt":0.5070968932165508,"score_spread":0.1736642075805253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}