{"id":"W4243150102","doi":"10.1158/1538-7445.am2019-lb-148","title":"Abstract LB-148: Combination treatment of the CHK1 inhibitor, SRA737, and low dose gemcitabine demonstrates profound synergy with anti-PDL1 inducing durable tumor regressions and modulating the immune microenvironment in small cell lung cancer","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision Nanosystems (Canada)","funders":"","keywords":"Gemcitabine; Cancer research; Immune system; Immune checkpoint; Cytotoxic T cell; Tumor microenvironment; Regimen; Lung cancer; Medicine; Blockade; Immunotherapy; Cancer; Pharmacology; Immunology; Biology; Oncology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006961288,0.0002343969,0.0004313394,0.0001770954,0.0003891655,0.00006157081,0.0001636423,0.00006417913,0.00007441529],"category_scores_gemma":[0.00006566351,0.0001215873,0.00004400311,0.0004982146,0.000600432,0.0001296757,0.000243295,0.0005504235,0.000001177291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001031366,"about_ca_system_score_gemma":0.0005831208,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008752522,"about_ca_topic_score_gemma":0.001718582,"domain_scores_codex":[0.9977172,0.0001877151,0.0003533287,0.0004927429,0.0006252452,0.0006237531],"domain_scores_gemma":[0.9987246,0.0003398166,0.0001608245,0.0004811616,0.0001804574,0.0001131465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003529025,0.0003124275,0.5359415,0.001097679,0.0001345293,0.00002448592,0.00193556,0.0005018102,0.4569907,0.00002251545,0.0000547307,0.002631231],"study_design_scores_gemma":[0.004427863,0.0004961505,0.7901652,0.003163525,0.00005125578,0.00001203623,0.001951876,0.001252248,0.1982451,0.00002137568,0.00006725749,0.0001461062],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9707696,0.02327791,4.500011e-7,0.002891288,0.00007156986,0.002659638,0.00002092834,0.000009950621,0.0002986387],"genre_scores_gemma":[0.9920857,0.006188275,0.00003126799,0.00002051288,0.00006490034,0.0006918663,0.000004930617,0.00003811451,0.0008744429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2587456,"threshold_uncertainty_score":0.9978483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02671144682847327,"score_gpt":0.3339614798496113,"score_spread":0.307250033021138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}