{"id":"W4243150102","doi":"10.1158/1538-7445.am2019-lb-148","title":"Abstract LB-148: Combination treatment of the CHK1 inhibitor, SRA737, and low dose gemcitabine demonstrates profound synergy with anti-PDL1 inducing durable tumor regressions and modulating the immune microenvironment in small cell lung cancer","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision Nanosystems (Canada)","funders":"","keywords":"Gemcitabine; Cancer research; Immune system; Immune checkpoint; Cytotoxic T cell; Tumor microenvironment; Regimen; Lung cancer; Medicine; Blockade; Immunotherapy; Cancer; Pharmacology; Immunology; Biology; Oncology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000114838,0.0003444916,0.0005451491,0.0003051923,0.0001587258,0.0002877871,0.0002987885,0.0002701694,0.001965844],"category_scores_gemma":[0.0000954182,0.00009943384,0.0002488906,0.0002098775,0.00021743,0.0001499679,0.0001260626,0.0008016966,0.0004067627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000221081,"about_ca_system_score_gemma":0.0004769283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001280693,"about_ca_topic_score_gemma":0.002359262,"domain_scores_codex":[0.9998838,0.00002273674,0.00001131012,0.00001433499,0.00002685751,0.00004094847],"domain_scores_gemma":[0.9999095,0.00001467341,0.00001587458,0.000009157583,0.000007089725,0.00004372119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006171641,0.002134248,0.000800043,0.0001175424,0.00004817993,0.0001288135,0.00002780456,0.0005405665,0.97557,0.0001182914,0.001000551,0.01334236],"study_design_scores_gemma":[0.0008912951,0.02392443,0.006724907,0.00001225107,0.0001092264,0.0003854182,0.0000301058,0.002123897,0.9633859,0.00003634405,0.002362915,0.00001317261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968796,0.0008824886,0.0002817434,0.00009779188,0.00004538269,0.00004379771,0.000372066,0.000119575,0.00127754],"genre_scores_gemma":[0.9973104,0.0003361769,0.0004960449,0.00004093499,0.0000165621,0.00004273201,0.0006133633,0.0000123903,0.001131408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001965844,"threshold_uncertainty_score":0.006576419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02671144682847327,"score_gpt":0.3339614798496113,"score_spread":0.307250033021138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}