{"id":"W4243188960","doi":"10.32920/ryerson.14661819.v1","title":"The PH domain from the Toxoplasma gondii PH-containing protein-1 (TgPH1) serves as an ectopic reporter of phosphatidylinositol 3-phosphate in mammalian cells","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Toronto Metropolitan University; University of Toronto","funders":"","keywords":"Endosome; Phosphatidylinositol; Pleckstrin homology domain; Cell biology; Effector; Biology; Organelle; Biochemistry; Chemistry; Signal transduction; Intracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008696761,0.0003638482,0.00019787,0.0002150979,0.000182115,0.0002466796,0.0002548647,0.0003437449,0.001212773],"category_scores_gemma":[0.00007337314,0.0001741621,0.0002097803,0.0002715642,0.0002199689,0.000198769,0.0002898559,0.0005816818,0.0007095372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004227448,"about_ca_system_score_gemma":0.0001745796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006126793,"about_ca_topic_score_gemma":0.001122028,"domain_scores_codex":[0.9998838,0.0000154287,0.00001058495,0.00002881181,0.00004209496,0.0000193468],"domain_scores_gemma":[0.9999468,0.00001320891,0.00001478453,0.000008203123,0.00000387221,0.00001312996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003914841,0.00001029784,0.0001373737,0.0000330664,0.000002130943,0.00003757911,0.00000944703,0.00003388478,0.9989618,0.0001451069,0.00004401344,0.0005461971],"study_design_scores_gemma":[0.00001405094,0.00006836891,0.003101337,0.000005839925,0.000008260131,0.0004837476,0.00001937145,0.0009058619,0.9885345,0.00006786688,0.006787505,0.000003342058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762623,0.002828195,0.01178097,0.0003344935,0.00009324276,0.0001060692,0.003627593,0.0002251034,0.004742128],"genre_scores_gemma":[0.9697257,0.002000226,0.01081485,0.0001455045,0.000018296,0.00009038232,0.008008469,0.00008588596,0.009110814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001212773,"threshold_uncertainty_score":0.004057109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01567988773705286,"score_gpt":0.2665798824656125,"score_spread":0.2508999947285597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}