{"id":"W4243210036","doi":"10.1093/neuonc/nox083.123","title":"IMMU-13. LARGE SCALE TUMOR MUTATIONAL BURDEN ANALYSIS OF PEDIATRIC TUMORS PROVIDES A DIAGNOSTIC TOOL FOR GERMLINE PREDISPOSITION AND REVEALS NOVEL CANDIDATES FOR IMMUNE CHECKPOINT INHIBITION","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"","keywords":"Somatic hypermutation; Germline; Germline mutation; Mutation; Exome sequencing; Cancer research; Cancer; DNA mismatch repair; Biology; Deep sequencing; Genetics; Medicine; Gene; DNA repair; Genome; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007869112,0.000516262,0.0004774423,0.001159626,0.0002920353,0.0005352545,0.000347939,0.0004436352,0.003453],"category_scores_gemma":[0.0008633059,0.0003148747,0.0003284008,0.0008285089,0.0002278301,0.0002027871,0.0005394853,0.0003997179,0.0012959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004959026,"about_ca_system_score_gemma":0.000480224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001223084,"about_ca_topic_score_gemma":0.003410193,"domain_scores_codex":[0.9997326,0.00003175451,0.00001689144,0.0001018982,0.00007574734,0.00004107121],"domain_scores_gemma":[0.9996159,0.0001062827,0.0001093398,0.00004442965,0.00005620914,0.00006765621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002207955,0.000166181,0.476117,0.0005694357,0.0003880408,0.001252148,0.0002569834,0.006585806,0.3377582,0.001655109,0.01368203,0.1593612],"study_design_scores_gemma":[0.0001791773,0.001037284,0.6255631,0.0001529737,0.0003953763,0.006502134,0.0001580559,0.05553484,0.2558425,0.00238439,0.05219293,0.0000572184],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8923503,0.002836291,0.04519831,0.0004010411,0.00006070564,0.0002426578,0.04549315,0.004238782,0.00917885],"genre_scores_gemma":[0.8618228,0.0009937953,0.08800038,0.0002771405,0.00003231105,0.0003472,0.04467884,0.0005681107,0.003279243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003453,"threshold_uncertainty_score":0.01155138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01156916159707395,"score_gpt":0.2890082230358321,"score_spread":0.2774390614387582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}