{"id":"W4243233456","doi":"10.2139/ssrn.3904961","title":"Mitophagy Enhancer Identified in Repurposing Screen for Parkinson's Disease Therapeutics","year":2021,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; Toronto Western Hospital; University of Toronto","funders":"","keywords":"Repurposing; Enhancer; Mitophagy; Parkinson's disease; Drug repositioning; Medicine; Disease; Computational biology; Pharmacology; Engineering; Biology; Autophagy; Internal medicine; Genetics; Drug; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001601029,0.0003054322,0.0005290502,0.000513075,0.000294705,0.0002640628,0.0002329257,0.0003730952,0.00578434],"category_scores_gemma":[0.0002097117,0.0001550993,0.0003999969,0.0002547962,0.0001180556,0.0001372036,0.0002611223,0.0004662854,0.001188181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001822743,"about_ca_system_score_gemma":0.0002411189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004118287,"about_ca_topic_score_gemma":0.001484082,"domain_scores_codex":[0.9998446,0.00001006231,0.00001137096,0.00003055565,0.00007979623,0.00002373792],"domain_scores_gemma":[0.9999238,0.00001808397,0.00001674352,0.000007521703,0.00001818948,0.00001567642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001590162,0.00005730379,0.0007502949,0.0001250976,0.00002644367,0.000268264,0.00001163177,0.00009967107,0.9880193,0.0001448023,0.0004485489,0.009889613],"study_design_scores_gemma":[0.0001023016,0.0008125681,0.01944213,0.00004740692,0.0002443933,0.001930736,0.00004635712,0.001119628,0.9500253,0.0001696087,0.02603845,0.00002119293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9659851,0.005477113,0.009397579,0.0003919017,0.000168795,0.0002689925,0.004489665,0.000884064,0.01293666],"genre_scores_gemma":[0.9525462,0.003018825,0.01463405,0.0005392584,0.00003330359,0.0001421385,0.01080174,0.0001134916,0.01817085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00578434,"threshold_uncertainty_score":0.01935053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01904383407342394,"score_gpt":0.296261745225435,"score_spread":0.2772179111520111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}