{"id":"W4243315597","doi":"10.1016/j.bmcl.2009.07.113","title":"C-5 substituted heteroaryl-3-pyridinecarbonitriles as PKCθ inhibitors: Part II","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Protein kinase C; Stereochemistry; Chemical synthesis; Pharmacology; In vitro; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000279654,0.0005497058,0.0004834842,0.0004954897,0.0002443546,0.0002833637,0.000595629,0.0003522542,0.003733783],"category_scores_gemma":[0.0001435246,0.0002315495,0.0003662467,0.0003828904,0.0002222745,0.000451729,0.0002807445,0.0005411042,0.001285735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004871122,"about_ca_system_score_gemma":0.0003383626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001148527,"about_ca_topic_score_gemma":0.001634968,"domain_scores_codex":[0.9998741,0.00002301906,0.000008516135,0.00001603303,0.00002559988,0.00005271453],"domain_scores_gemma":[0.99997,0.000005461495,0.000008139738,0.000005798438,0.000004262741,0.00000638695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001738493,0.0008785194,0.0004055333,0.001033083,0.00008762531,0.0005952989,0.0001755002,0.005055574,0.8476415,0.005528178,0.003412844,0.1334478],"study_design_scores_gemma":[0.0005805267,0.00734967,0.006434129,0.0001316375,0.0002237492,0.001627109,0.00009459086,0.004088446,0.9077122,0.0009666255,0.07068935,0.0001019127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8181684,0.1267605,0.01078004,0.0007923185,0.0005174132,0.0004902366,0.0009109217,0.0004192652,0.04116086],"genre_scores_gemma":[0.8979366,0.07676333,0.003603217,0.0004155084,0.0002442847,0.0002179537,0.0009338686,0.00005952921,0.01982574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003733783,"threshold_uncertainty_score":0.01249075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007540314342123414,"score_gpt":0.2224573929241986,"score_spread":0.2149170785820752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}