{"id":"W4243371549","doi":"10.1093/jac/dkab148","title":"The case for ‘conservative pharmacotherapy’—authors’ response","year":2021,"lang":"en","type":"letter","venue":"Journal of Antimicrobial Chemotherapy","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services; University of Alberta Hospital; Alberta Hospital Edmonton; Mount Sinai Hospital","funders":"","keywords":"Premise; Dosing; Intensive care medicine; Medicine; Pharmacodynamics; Pharmacotherapy; Clinical Practice; Therapeutic drug monitoring; Statement (logic); Medical physics; Clinical pharmacology; Drug; Computer science; Pharmacology; Risk analysis (engineering); Pharmacokinetics; Family medicine; Political science; Internal medicine; Epistemology; Philosophy; Law","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009006198,0.0008416012,0.001754896,0.000820333,0.003819609,0.005093372,0.003401759,0.07313588,0.007063334],"category_scores_gemma":[0.0742631,0.000882078,0.001918507,0.0008299418,0.006670688,0.007582793,0.002975161,0.08330185,0.005910063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00405311,"about_ca_system_score_gemma":0.005109648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002532306,"about_ca_topic_score_gemma":0.003972115,"domain_scores_codex":[0.992652,0.00212693,0.001089663,0.001122396,0.002240643,0.0007685047],"domain_scores_gemma":[0.9705593,0.01567742,0.002206945,0.001125122,0.006637481,0.003793688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002266395,0.0000226811,0.0002444773,0.00005993996,0.00001294858,0.001801489,0.0001765348,0.00006166891,0.00008584988,0.002419266,0.9901591,0.004933326],"study_design_scores_gemma":[0.00006213845,0.0000437011,0.0004849034,0.0004243461,0.00001957258,0.005203751,0.0005244184,0.0003163352,0.0002055196,0.008122151,0.9845023,0.00009097968],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0001400541,0.0007766564,0.00009661682,0.9798038,0.01853655,0.000006967598,0.00001729469,0.00003212819,0.0005898691],"genre_scores_gemma":[0.00129659,0.0003380486,0.0001695931,0.9777957,0.01954219,0.00001404522,0.000006908629,0.00001453205,0.0008223344],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.07313588,"threshold_uncertainty_score":0.04762989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03463824566960792,"score_gpt":0.3368648030921068,"score_spread":0.3022265574224989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}