{"id":"W4243379165","doi":"10.1002/ange.202105253","title":"Programmable RNA <i>N</i><sup>1</sup>‐Methyladenosine Demethylation by a Cas13d‐Directed Demethylase","year":2021,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Key Research and Development Program of China","keywords":"Demethylase; Demethylation; N6-Methyladenosine; Chemistry; RNA; Biochemistry; Methyltransferase; DNA; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002301051,0.0003685599,0.0001902904,0.0001670685,0.0001662159,0.0003368077,0.0004222784,0.0003472344,0.001385497],"category_scores_gemma":[0.0002092491,0.0002013506,0.0003003849,0.00009889381,0.0003207637,0.0001802015,0.0002704188,0.0006517327,0.0005329179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003315355,"about_ca_system_score_gemma":0.0002249592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00056983,"about_ca_topic_score_gemma":0.0009098398,"domain_scores_codex":[0.9998077,0.00002136148,0.00002152456,0.00006682995,0.00005228218,0.00003022558],"domain_scores_gemma":[0.999826,0.00003719289,0.00006268761,0.00003793883,0.00001414199,0.0000219576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002724003,0.000009420891,0.0001029374,0.00002222529,0.000003721075,0.00003113955,0.000006422591,0.0001202186,0.9975535,0.0002983417,0.00008534666,0.001739522],"study_design_scores_gemma":[0.000003400744,0.00002814168,0.0002337393,0.00000161921,0.000003160418,0.00007721722,0.000002939901,0.001052774,0.9963201,0.00002749643,0.002245195,0.00000410437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8370447,0.001457549,0.1462498,0.0003564916,0.0002149096,0.0002361827,0.001403997,0.003278711,0.009757675],"genre_scores_gemma":[0.934356,0.0005363689,0.05648999,0.0001337079,0.00001775775,0.00009135003,0.0008273107,0.0002409968,0.00730653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001385497,"threshold_uncertainty_score":0.004634976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01275058351921749,"score_gpt":0.2503415277032663,"score_spread":0.2375909441840488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}