{"id":"W4243472008","doi":"10.1016/j.vascn.2017.09.003","title":"Cytoplasmic Distribution of HIV-1 Tat Sensitizes Jurkat T Cells to Sulphamethoxazole-hydroxylamine Induced Toxicity","year":2017,"lang":"en","type":"article","venue":"Journal of Pharmacological and Toxicological Methods","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Jurkat cells; Hydroxylamine; Toxicity; Human immunodeficiency virus (HIV); Chemistry; Virology; Pharmacology; Medicine; Biochemistry; Immunology; T cell; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008645537,0.0001756133,0.0001666412,0.0001507927,0.0003845592,0.0004103993,0.0001609954,0.000294843,0.003144275],"category_scores_gemma":[0.00008579047,0.000169968,0.0002249631,0.0001856381,0.0002469424,0.0002030354,0.0002005813,0.000543059,0.0007178235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003463736,"about_ca_system_score_gemma":0.0002748556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00168658,"about_ca_topic_score_gemma":0.002136296,"domain_scores_codex":[0.9998502,0.00002553785,0.000009520289,0.00002666759,0.00003744049,0.00005068984],"domain_scores_gemma":[0.9999189,0.00002268084,0.00001510135,0.00001277252,0.00001512998,0.00001538396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006515619,0.000007598959,0.00015867,0.0000219554,0.00000283938,0.00007472617,0.00003423818,0.00002006698,0.999068,0.00009669343,0.0000225008,0.000427596],"study_design_scores_gemma":[0.00001475581,0.0001942299,0.01130054,0.0000081526,0.00001892038,0.000477824,0.0001746427,0.0005699294,0.9850119,0.00005522154,0.002169113,0.00000474494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924949,0.00125776,0.002299824,0.0001594093,0.00003462197,0.0000141949,0.0002423534,0.00005244804,0.003444334],"genre_scores_gemma":[0.9957035,0.0004490502,0.0008787114,0.00003104459,0.0000101131,0.00001161384,0.0002223116,0.00001235158,0.002681267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003144275,"threshold_uncertainty_score":0.01051861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06173652721216818,"score_gpt":0.4144234767855426,"score_spread":0.3526869495733744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}