{"id":"W4243499030","doi":"10.4236/health.2018.108081","title":"Crystal Structures of Human 17&amp;lt;i&amp;gt;β&amp;lt;/i&amp;gt;-Hydroxysteroid Dehydrogenase Type 1 Complexed with the Dual-Site Inhibitor EM-139","year":2018,"lang":"en","type":"article","venue":"Health","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Theratechnologies (Canada); Université Laval","funders":"Argonne National Laboratory","keywords":"Hydroxysteroid dehydrogenase; Moiety; Chemistry; Stereochemistry; Enzyme; Dehydrogenase; Estrone; Hydrogen bond; Binding site; Molecule; Biochemistry; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000493654,0.0004792938,0.0005375856,0.0001086279,0.0006148895,0.0000608952,0.0003377073,0.0003798034,0.0001470499],"category_scores_gemma":[0.00005477413,0.0003303142,0.0001725815,0.000291352,0.0005262952,0.00001179462,0.0002115229,0.0003757279,0.0001122366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005949234,"about_ca_system_score_gemma":0.0003032523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001377109,"about_ca_topic_score_gemma":0.004326359,"domain_scores_codex":[0.9970998,0.0003799469,0.0005829191,0.0006906512,0.0004428963,0.0008038253],"domain_scores_gemma":[0.9977037,0.00004126682,0.0004693175,0.00113559,0.0002747443,0.000375371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004715505,0.0001413652,0.0004834031,0.0001421998,0.0002157849,0.000004179106,0.001178478,0.00004172215,0.9523878,0.0001168055,0.04454046,0.0002763043],"study_design_scores_gemma":[0.005537597,0.007027928,0.004493544,0.0004375859,0.0003165762,0.0007459903,0.0001972025,0.00004085732,0.2946189,0.0002371654,0.6846416,0.001705054],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929908,0.004467767,0.0002770715,0.0003813891,0.0002942216,0.00070753,0.0001267501,0.00005968107,0.0006948105],"genre_scores_gemma":[0.993382,0.0001416274,0.001545652,0.0009214531,0.0008923727,0.00002016296,0.001198352,0.00009594344,0.001802415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6577688,"threshold_uncertainty_score":0.9999149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01745477142764114,"score_gpt":0.2885894700360606,"score_spread":0.2711346986084194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}