{"id":"W4243555656","doi":"10.1021/ja074209p","title":"Isostable DNA","year":2007,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Merck Canada","keywords":"Chemistry; Duplex (building); DNA; DNA microarray; Oligonucleotide; Nucleic acid; Base pair; Multiplex; Nucleic acid thermodynamics; Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid; Sequence (biology); Gene; Computational biology; Combinatorial chemistry; Biochemistry; Base sequence; Gene expression; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003695851,0.0000843169,0.0001611618,0.000008131733,0.0000497153,0.000008661033,0.0002507838,0.00005141834,8.382874e-7],"category_scores_gemma":[0.00008900475,0.00005043784,0.0004780675,0.0001908727,0.0002909003,0.000002400392,0.00009493791,0.0001628301,3.335219e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003445802,"about_ca_system_score_gemma":0.00003262217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004059347,"about_ca_topic_score_gemma":9.329378e-7,"domain_scores_codex":[0.9993073,0.0000168738,0.0002328499,0.00009871049,0.0001702519,0.0001740344],"domain_scores_gemma":[0.9991898,0.00001752276,0.0004197302,0.0001904359,0.0001211524,0.00006135889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004433227,0.00003120308,0.0009338497,0.000001451457,0.00006493883,7.275704e-7,0.00001120481,8.951582e-7,0.9849849,0.00000219592,0.01082737,0.003096878],"study_design_scores_gemma":[0.00009978829,0.00007839932,0.0005775263,0.00000737548,0.00002963746,0.00004388669,0.0001421558,0.00000377962,0.9763756,0.00006897924,0.02249962,0.00007326093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959668,0.00009679624,0.003079335,0.0005748867,0.00004364603,0.00002240867,0.000001704117,0.000005628715,0.0002087788],"genre_scores_gemma":[0.9829617,0.0001183432,0.01485587,0.001528202,0.0003725244,1.301958e-7,0.00000123706,0.000008755475,0.0001532529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01300513,"threshold_uncertainty_score":0.2056796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005992103115448487,"score_gpt":0.2708888307903984,"score_spread":0.2648967276749499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}