{"id":"W4243555656","doi":"10.1021/ja074209p","title":"Isostable DNA","year":2007,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Merck Canada","keywords":"Chemistry; Duplex (building); DNA; DNA microarray; Oligonucleotide; Nucleic acid; Base pair; Multiplex; Nucleic acid thermodynamics; Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid; Sequence (biology); Gene; Computational biology; Combinatorial chemistry; Biochemistry; Base sequence; Gene expression; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006889799,0.0008761521,0.0005127857,0.001154996,0.0003908171,0.001015786,0.00066779,0.0008805651,0.007989393],"category_scores_gemma":[0.001365908,0.0004968051,0.0004188256,0.0006185035,0.0005449192,0.000788365,0.0008302808,0.001312584,0.007399333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003754475,"about_ca_system_score_gemma":0.0002744534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001535454,"about_ca_topic_score_gemma":0.0002304727,"domain_scores_codex":[0.9985611,0.0002334192,0.00008446629,0.0005216662,0.000484606,0.0001147077],"domain_scores_gemma":[0.9991401,0.0001886042,0.0001855728,0.0001733837,0.0002027706,0.0001095617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001241639,0.00005929714,0.0004641434,0.0002602206,0.00001719936,0.00008789504,0.000116179,0.0002121342,0.9492137,0.004926278,0.001167449,0.04335135],"study_design_scores_gemma":[0.0000205612,0.0003566493,0.0005779964,0.00004264693,0.00002504169,0.0007591803,0.00003837234,0.0008049756,0.9166791,0.001087853,0.07958204,0.0000255911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.330384,0.01768524,0.5679359,0.0009993459,0.001185066,0.001119911,0.002857777,0.006203621,0.07162925],"genre_scores_gemma":[0.6437048,0.007868669,0.225864,0.001911591,0.0002798353,0.001146021,0.007123497,0.0006760216,0.1114255],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.007989393,"threshold_uncertainty_score":0.0267272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005992103115448487,"score_gpt":0.2708888307903984,"score_spread":0.2648967276749499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}