{"id":"W4243628135","doi":"10.1172/jci200316409","title":"Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood","year":2003,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of Calgary; University of Alberta; Simon Fraser University; University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Fondation pour la Recherche Médicale; Children's Hospital Foundation; Michael Smith Health Research BC; Canadian Diabetes Association","keywords":"Immunology; Peripheral blood; NOD mice; Autoimmunity; Type 1 diabetes; Major histocompatibility complex; Autoimmune diabetes; Nod; Avidity; Diabetes mellitus; Autoimmune disease; Medicine; Peripheral; Antigen; Biology; Immune system; Endocrinology; Antibody; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001263195,0.00008060091,0.0003027702,0.00006561153,0.00000982637,0.000005898289,0.00008884374,0.0002051841,0.000005233823],"category_scores_gemma":[0.001132662,0.00007767489,0.0001171932,0.0001445553,0.0001105061,0.00001619683,0.000008629745,0.0001831439,2.399141e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000163265,"about_ca_system_score_gemma":0.0001478496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002402036,"about_ca_topic_score_gemma":0.00001993158,"domain_scores_codex":[0.9981055,0.0003006581,0.001209957,0.0001261242,0.0001482691,0.0001094696],"domain_scores_gemma":[0.9985108,0.0001034367,0.001074725,0.00009025757,0.0001738155,0.00004693392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004643599,0.0003788677,0.1800747,0.00001678381,0.00004811792,0.000001257679,0.00005604818,0.0004087642,0.8184112,0.00002862769,0.000135921,0.0003932147],"study_design_scores_gemma":[0.002098719,0.0009464088,0.269266,0.0001327091,0.00005864816,0.000003565432,0.0001749512,0.0008577644,0.7254923,0.0004811466,0.0003933742,0.00009435774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990683,0.0003972267,0.00003843251,0.0000767616,0.0001979699,0.00008883822,0.00002159313,0.000001367231,0.0001095134],"genre_scores_gemma":[0.9991953,0.0001993831,0.0004449132,0.00004719228,0.00002943044,0.000001785125,0.00003964264,0.000008176952,0.00003414515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09291895,"threshold_uncertainty_score":0.316749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02065972628916456,"score_gpt":0.2762189708846089,"score_spread":0.2555592445954443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}