{"id":"W4243667708","doi":"10.1158/0008-5472.can-03-3852","title":"Association of Breast Cancer DNA Methylation Profiles with Hormone Receptor Status and Response to Tamoxifen","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":322,"is_retracted":false,"has_abstract":true,"ca_institutions":"inVentiv Health Clinical","funders":"National Institute of Environmental Health Sciences","keywords":"DNA methylation; Tamoxifen; Methylation; Estrogen receptor; Estrogen receptor alpha; Biology; Breast cancer; Progesterone receptor; Internal medicine; Cancer research; Antiestrogen; Estrogen; Epigenetics; Cancer; Endocrinology; Gene; Medicine; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00107392,0.00008630528,0.0001101104,0.0001062807,0.00008473413,0.00002717956,0.00008186278,0.0001115647,0.00002453615],"category_scores_gemma":[0.0001903363,0.0000753785,0.00001870607,0.0002902719,0.00006061839,0.000006992677,0.0000694696,0.0001050353,0.000002531453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002522835,"about_ca_system_score_gemma":0.0004614951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007694887,"about_ca_topic_score_gemma":0.0004570351,"domain_scores_codex":[0.998672,0.0002010222,0.0001449752,0.0002757704,0.0004126306,0.0002935816],"domain_scores_gemma":[0.9989923,0.00004287633,0.00007701388,0.0001726539,0.0005886197,0.0001265413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00192216,0.00002584813,0.01136039,0.00001533224,0.00005224093,2.293574e-7,0.0002898339,0.000445999,0.9809853,0.00001564739,0.0002716549,0.004615293],"study_design_scores_gemma":[0.000743964,0.0004793675,0.1719563,0.00003072327,0.000009738349,2.018171e-7,0.00008138911,0.000002286088,0.8200979,0.00009438777,0.006405762,0.00009807478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937298,0.003160577,0.0002254696,0.002235281,0.00003491006,0.0003688071,0.0001826454,0.00000491429,0.00005759983],"genre_scores_gemma":[0.9947429,0.003673206,0.0005390432,0.00002537618,0.0001377987,0.000164589,0.00003695481,0.00002040276,0.0006597596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1608875,"threshold_uncertainty_score":0.3073846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02260002131992832,"score_gpt":0.3520918319834126,"score_spread":0.3294918106634843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}