{"id":"W4243681505","doi":"10.21203/rs.3.rs-60003/v1","title":"STAU2 Protein Level is Controlled by Caspases and the CHK1 Pathway and Regulates Cell Cycle Progression in the Non-transformed hTERT-RPE1 Cells","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cell cycle progression; Apoptosis; Cell biology; Cell cycle; Caspase; Cell; Cancer research; Telomerase reverse transcriptase; Cell cycle checkpoint; CHEK1; Biology; Programmed cell death; Chemistry; Computer science; Telomerase; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008546443,0.0002415783,0.0002663118,0.0006788307,0.0003521734,0.0008720725,0.0002290444,0.0003564595,0.002610156],"category_scores_gemma":[0.0001586036,0.0001880271,0.0002494032,0.0004191855,0.0003092224,0.0004299234,0.0001968467,0.0005729413,0.0009261395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005843235,"about_ca_system_score_gemma":0.0002932797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002091617,"about_ca_topic_score_gemma":0.002082108,"domain_scores_codex":[0.9998649,0.00001365022,0.000008762739,0.00003861069,0.00003389162,0.00004007681],"domain_scores_gemma":[0.9998616,0.00002517363,0.00003408449,0.00001844033,0.0000224738,0.000038156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002873676,0.000017012,0.0004428013,0.00002018159,0.000005042954,0.00005857725,0.00002140946,0.00002442399,0.998002,0.0002538709,0.00007132962,0.0007961637],"study_design_scores_gemma":[0.00001275153,0.00004563552,0.02057863,0.000003560674,0.00001028389,0.0001787685,0.00005475866,0.0005592037,0.9767869,0.0001281679,0.00163508,0.00000618643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903705,0.003287922,0.001273187,0.0001525431,0.0000345671,0.00000956229,0.001929862,0.0001706145,0.002771342],"genre_scores_gemma":[0.9897389,0.0007352049,0.0007040941,0.0000367799,0.00001056428,0.00001738659,0.001657917,0.00005951776,0.007039645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002610156,"threshold_uncertainty_score":0.008731782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02585352965954116,"score_gpt":0.3223131911661173,"score_spread":0.2964596615065761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}