{"id":"W4243697403","doi":"10.31219/osf.io/wnhu9","title":"Homology Directed Repair in Zebrafish: Witchcraft and Wizardry?","year":2020,"lang":"en","type":"preprint","venue":"","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Zebrafish; Mutagenesis; CRISPR; Computational biology; Gene; Biology; Mutant; Zinc finger; Genome editing; Genetics; Homology (biology); Zinc finger nuclease; Homology modeling; Model organism; Genetic screen; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001547532,0.0006178566,0.0008563807,0.0009053883,0.0004031315,0.00127813,0.0007718362,0.001291203,0.005452943],"category_scores_gemma":[0.001185846,0.0005834344,0.0004995674,0.0006107303,0.001936582,0.002890202,0.0008001713,0.001994054,0.003336423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001191295,"about_ca_system_score_gemma":0.001139598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002187044,"about_ca_topic_score_gemma":0.003577755,"domain_scores_codex":[0.999421,0.00007185334,0.00003531964,0.0001339381,0.0002688934,0.00006905536],"domain_scores_gemma":[0.9997101,0.00005822621,0.00006167327,0.0000650265,0.00005836675,0.00004646982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000424726,0.00007767614,0.0008768721,0.002558705,0.0001357375,0.0005976157,0.0004930188,0.001128813,0.3609765,0.1253253,0.02352159,0.4838834],"study_design_scores_gemma":[0.00008096771,0.0008600863,0.004444978,0.001178447,0.0001875962,0.002609831,0.0002965511,0.00164119,0.2528686,0.05468816,0.6809556,0.0001880923],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.05190251,0.5184267,0.295289,0.03035332,0.005793343,0.0003858105,0.001299683,0.002664057,0.09388547],"genre_scores_gemma":[0.2888327,0.3457726,0.1885257,0.01021283,0.0009169655,0.0004267215,0.001304481,0.001745288,0.1622628],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005452943,"threshold_uncertainty_score":0.01824188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009498215317748695,"score_gpt":0.2827183235796598,"score_spread":0.2732201082619111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}