{"id":"W4243783261","doi":"10.21203/rs.2.18945/v1","title":"Plasma sex hormone-binding globulin predicts neurodegeneration and clinical progression in prodromal Alzheimer's disease","year":2019,"lang":"en","type":"preprint","venue":"Research Square","topic":"Biochemical effects in animals","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; National Natural Science Foundation of China; Eisai; Genentech; IXICO; Northern California Institute for Research and Education; Fudan University; Novartis Pharmaceuticals Corporation; Biogen; BioClinica; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; F. Hoffmann-La Roche; University of Southern California; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Neurodegeneration; Sex hormone-binding globulin; Disease; Alzheimer's disease; Medicine; Hormone; Internal medicine; Endocrinology; Androgen","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004963827,0.0005245356,0.0004023057,0.0006936289,0.0002385171,0.0005890993,0.000201697,0.0005710963,0.002505095],"category_scores_gemma":[0.001359516,0.0002305727,0.000194982,0.0003310844,0.0003039026,0.0002882811,0.0002584809,0.0005572567,0.0004706133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000174035,"about_ca_system_score_gemma":0.0001607097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001513433,"about_ca_topic_score_gemma":0.0009933216,"domain_scores_codex":[0.9999117,0.00002647415,0.000006733455,0.00002317814,0.00001609832,0.00001585406],"domain_scores_gemma":[0.9994932,0.0001672135,0.0001257238,0.00005216052,0.00004553819,0.0001161803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006332318,0.0003558094,0.9744611,0.0000332259,0.0002029216,0.0005482502,0.0001752674,0.0001145422,0.007518788,0.000108625,0.0005530784,0.009595986],"study_design_scores_gemma":[0.00002852507,0.0002711894,0.9977446,0.000007435393,0.00005929558,0.0005103201,0.0001064039,0.0002187814,0.0005708212,0.0002218369,0.0002565431,0.0000041789],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984809,0.0004193578,0.0001138286,0.00006012734,0.00002166598,0.000004555629,0.0002297297,0.000009121426,0.0006608661],"genre_scores_gemma":[0.997878,0.0001714331,0.0001327036,0.0000310723,0.00002326429,0.000005402327,0.0002576865,0.000007062943,0.001493385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002505095,"threshold_uncertainty_score":0.008380353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09960996096451731,"score_gpt":0.4615136002985171,"score_spread":0.3619036393339998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}