{"id":"W4243799857","doi":"10.1177/117693510700300028","title":"The Roles of β-Tubulin Mutations and Isotype Expression in Acquired Drug Resistance","year":2007,"lang":"en","type":"article","venue":"Cancer Informatics","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Tubulin; Microtubule; Paclitaxel; Isotype; Biology; Cell biology; Taxane; Mitosis; Biochemistry; Genetics; Cancer; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002117956,0.00006282162,0.00006894254,0.00002464226,0.00005998344,0.00001151032,0.0001023556,0.00005480841,0.000001772393],"category_scores_gemma":[0.00003409297,0.00004757439,0.00001930973,0.00006412574,0.00008332517,0.000006394916,0.00005097566,0.00003591531,5.923845e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001139562,"about_ca_system_score_gemma":0.00004587065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004097701,"about_ca_topic_score_gemma":0.001752414,"domain_scores_codex":[0.9994689,0.000009221713,0.0002828137,0.00005091127,0.00006256465,0.0001255791],"domain_scores_gemma":[0.999625,0.00002475127,0.0001136564,0.0001565156,0.00005318386,0.00002686566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005240246,0.00006839725,0.01202606,0.0003556191,0.000049501,0.000001433039,0.009970582,0.0006964729,0.926703,0.0009600041,0.009803741,0.03884115],"study_design_scores_gemma":[0.0007975962,0.00003319973,0.003846509,0.000150421,0.00001414207,0.000002120853,0.004445926,0.0004801281,0.8546923,0.0003252215,0.135012,0.0002003789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917973,0.003923147,0.002977018,0.00009969349,0.00006827235,0.000120802,0.00001454873,0.000003242038,0.0009959443],"genre_scores_gemma":[0.99415,0.002969489,0.002002119,0.0001335737,0.00003821575,0.00001263187,0.00002864987,0.000007131454,0.0006581947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1252083,"threshold_uncertainty_score":0.1940027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005595623065697768,"score_gpt":0.2540744377805564,"score_spread":0.2484788147148587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}