{"id":"W4243909481","doi":"10.2165/00148581-200204040-00005","title":"Ethical Issues in Including Pediatric Cancer Patients in Drug Development Trials","year":2002,"lang":"en","type":"article","venue":"Pediatric Drugs","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medicine; Pharmacotherapy; Drug development; Intensive care medicine; Drug trial; Clinical trial; Drug; Cancer drugs; Cancer; MEDLINE; Oncology; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00235015,0.0002217742,0.0007121543,0.0003698264,0.0001019217,0.00002523517,0.0001289462,0.0001852442,0.0008262715],"category_scores_gemma":[0.002374187,0.0001800679,0.00008227293,0.001046412,0.00002203608,0.0001332372,0.0001714048,0.0009939123,0.0001765662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002816344,"about_ca_system_score_gemma":0.00008969513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007719874,"about_ca_topic_score_gemma":0.0001779045,"domain_scores_codex":[0.9971663,0.0003563366,0.0009684548,0.0003783078,0.0006140097,0.0005165981],"domain_scores_gemma":[0.9978845,0.001480603,0.0002362425,0.0001179075,0.00008188407,0.0001988279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001250919,0.0005937777,0.9572606,0.0002247891,0.00002243709,0.00003267295,0.006139104,0.000005472562,0.000001896577,0.00001355028,0.01493978,0.02064084],"study_design_scores_gemma":[0.01031123,0.00009746528,0.7102268,0.00007086107,0.0004949716,0.000002110203,0.0004673087,0.0003147245,0.00014093,0.0001042541,0.2771193,0.0006500642],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719727,0.01536609,8.871708e-7,0.007765323,0.0005947026,0.0005729544,0.000005896362,0.00004035452,0.003681059],"genre_scores_gemma":[0.9472227,0.04897055,0.0002641771,0.001348654,0.001385572,0.0001159463,0.000006137382,0.00002122047,0.0006650138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2621795,"threshold_uncertainty_score":0.9047093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.13700114065164,"score_gpt":0.4301196535979619,"score_spread":0.2931185129463219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}