{"id":"W4244011565","doi":"10.1158/0008-5472.can-18-3418","title":"Epigenetic Regulation of <i>NAMPT</i> by <i>NAMPT-AS</i> Drives Metastatic Progression in Triple-Negative Breast Cancer","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Natural Science Foundation of Shandong Province; China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"Triple-negative breast cancer; Epigenetics; Breast cancer; Cancer; Cancer research; Medicine; Triple negative; Epigenesis; Oncology; Biology; Internal medicine; DNA methylation; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001343387,0.0001580629,0.0002659817,0.0001594611,0.00015395,0.0002286968,0.0001169645,0.0001473449,0.001209831],"category_scores_gemma":[0.00009546178,0.000118752,0.0002691043,0.0001281283,0.0001927792,0.00008619877,0.000153302,0.0004014537,0.0002819308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003025906,"about_ca_system_score_gemma":0.0001942813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001441196,"about_ca_topic_score_gemma":0.002207089,"domain_scores_codex":[0.9998827,0.00001718,0.000009024484,0.00003207554,0.00003171769,0.00002727634],"domain_scores_gemma":[0.999944,0.000005382316,0.00001652128,0.000005559666,0.000008513045,0.00002008381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001185127,0.00001663055,0.001090418,0.00003862628,0.000008729276,0.00005760361,0.00001836513,0.00005369851,0.9973689,0.00008298615,0.0001440561,0.001001486],"study_design_scores_gemma":[0.00004363415,0.0004226665,0.0561466,0.0000156335,0.00006151818,0.0008116649,0.0001362619,0.004057501,0.930966,0.0001765327,0.007145417,0.00001657199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931257,0.001069755,0.002574556,0.000144405,0.00005673615,0.00003465689,0.0009577131,0.0001388776,0.001897728],"genre_scores_gemma":[0.9958147,0.0003839434,0.001075854,0.000112098,0.000007870418,0.00004597322,0.0006700167,0.00002414573,0.001865467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001441196,"threshold_uncertainty_score":0.004047275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03325761628537665,"score_gpt":0.4174628109197229,"score_spread":0.3842051946343462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}