{"id":"W4244013818","doi":"10.1002/0470028637.met042","title":"Calpain","year":2004,"lang":"en","type":"other","venue":"Handbook of Metalloproteins","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Calpain; Proteases; Protease; Papain; Active site; Gene isoform; Chemistry; Enzyme; Cysteine protease; Biochemistry; Catalytic triad; Intracellular; Binding site; Cell biology; Biophysics; Stereochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001305285,0.0002136584,0.0002535911,0.0001246109,0.00002314979,0.000006706893,0.0001307926,0.000438922,0.001579783],"category_scores_gemma":[0.00004325993,0.0001915111,0.0002007163,0.00005828025,0.0001116481,7.99617e-7,0.00005926218,0.00008393693,0.00006074662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001392926,"about_ca_system_score_gemma":0.0001399506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001319571,"about_ca_topic_score_gemma":0.0001715378,"domain_scores_codex":[0.9990966,0.00004890135,0.0002024684,0.0003106183,0.0001939138,0.0001475008],"domain_scores_gemma":[0.9992701,0.000002004324,0.0002093384,0.0004147502,0.00003607905,0.00006768835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001037201,0.0001723168,0.00002099541,0.0003583333,0.0004714866,0.00000634764,0.00001616264,0.00004166317,0.6810436,0.0005332772,0.3086404,0.008591696],"study_design_scores_gemma":[0.0005546183,0.0001404105,0.00001126711,0.0003298824,0.00003998632,0.000005585749,0.000003620492,0.000002056455,0.1860096,0.00009533814,0.8126101,0.0001975316],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.0005632928,0.05136687,0.1515651,0.0001573978,0.001111658,0.003289522,0.000189811,0.0002284308,0.7915279],"genre_scores_gemma":[0.002148043,0.000792771,0.005793083,0.00010953,0.0006484954,0.00008568975,0.0003835267,0.0003387855,0.9897001],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.5039697,"threshold_uncertainty_score":0.9993329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005674040733925804,"score_gpt":0.2146394745324861,"score_spread":0.2089654337985603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}