{"id":"W4244071037","doi":"10.1139/cjpp-79-6-533","title":"Diminished molecular response to doxorubicin and loss of cardioprotective effect of dexrazoxane in <i>Egr-1</i> deficient female mice","year":2001,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Dexrazoxane; Doxorubicin; Chemistry; Internal medicine; Pharmacology; Cancer research; Medicine; Endocrinology; Biology; Chemotherapy; Cancer; Anthracycline; Breast cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002094291,0.0009843445,0.000743973,0.001003341,0.0002893092,0.0004415697,0.0004498715,0.0008691566,0.00498238],"category_scores_gemma":[0.0002035781,0.0005290948,0.0004813238,0.0003146764,0.000840159,0.0005034143,0.0002549495,0.001548317,0.001060051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004469035,"about_ca_system_score_gemma":0.0003402016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001309987,"about_ca_topic_score_gemma":0.002134368,"domain_scores_codex":[0.9997255,0.00003669383,0.00002771323,0.00007952192,0.00005458872,0.00007595491],"domain_scores_gemma":[0.9995087,0.00004224902,0.0001965511,0.00005800666,0.0000313913,0.0001630206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004043436,0.0000425447,0.0001073148,0.00001640003,0.000005211321,0.00007488377,0.00001383885,0.00003734686,0.9985814,0.00008164559,0.00005089307,0.0005841643],"study_design_scores_gemma":[0.0001201789,0.0008377131,0.005292914,0.000009768607,0.00004628068,0.0005451984,0.000054931,0.000502262,0.9908963,0.00007271133,0.001608519,0.00001333279],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887332,0.001431617,0.004227073,0.0007018291,0.0001307936,0.00005799787,0.002499962,0.0005189214,0.001698538],"genre_scores_gemma":[0.9774968,0.001134178,0.003482033,0.0002357613,0.00004594394,0.0001573338,0.001504413,0.0002520815,0.01569152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00498238,"threshold_uncertainty_score":0.01666772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007496040216011675,"score_gpt":0.2656020086765606,"score_spread":0.2581059684605489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}