{"id":"W4244229571","doi":"10.1128/aac.01223-08","title":"Effects of Lipid-Based Oral Formulations on Plasma and Tissue Amphotericin B Concentrations and Renal Toxicity in Male Rats","year":2008,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Toxicity; Amphotericin B; Pharmacology; Plasma concentration; Oral administration; Pharmacokinetics; Medicine; Kidney; Chemistry; Internal medicine; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031468,0.0007629458,0.0005821103,0.0007050628,0.0003017733,0.0003833546,0.0003637783,0.0007871591,0.001876377],"category_scores_gemma":[0.0003617611,0.0005022371,0.0006137842,0.0003445256,0.0008634091,0.0009037533,0.0002353861,0.001391027,0.0003904598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003942744,"about_ca_system_score_gemma":0.0005986851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001623853,"about_ca_topic_score_gemma":0.001569905,"domain_scores_codex":[0.999702,0.00004041411,0.00002248217,0.00007581086,0.00005405159,0.0001050697],"domain_scores_gemma":[0.9993908,0.0001117624,0.0002260015,0.00005430489,0.0000680784,0.0001489983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02994628,0.003280141,0.0006499836,0.0001446517,0.0000636711,0.0002498523,0.000139984,0.0004523899,0.9567432,0.0002555757,0.0002020665,0.007872229],"study_design_scores_gemma":[0.0003841282,0.01388876,0.003118684,0.00001104455,0.0001389321,0.0001329095,0.000106493,0.0006837661,0.9806519,0.00012104,0.0007305078,0.00003195079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974003,0.0007363582,0.0007221629,0.0001304841,0.00004953174,0.00003294174,0.0003320715,0.00006272605,0.0005334308],"genre_scores_gemma":[0.9914757,0.001477158,0.001578232,0.0001044295,0.00004477701,0.00007447667,0.0003847951,0.00003987856,0.004820529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001876377,"threshold_uncertainty_score":0.006277144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03142761116997857,"score_gpt":0.3192114605675601,"score_spread":0.2877838493975815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}