{"id":"W4244341892","doi":"10.1142/18609475730043","title":"CODON-BASED DETECTION OF POSITIVE SELECTION CAN BE BIASED BY HETEROGENEOUS DISTRIBUTION OF POLAR AMINO ACIDS ALONG PROTEIN SEQUENCES","year":2006,"lang":"en","type":"article","venue":"","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institutes of Health","keywords":"Polar; Selection (genetic algorithm); Amino acid; Distribution (mathematics); Computer science; Computational biology; Biology; Genetics; Mathematics; Artificial intelligence; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003928423,0.0004141542,0.0007794801,0.001902904,0.0004424645,0.0008656291,0.000336334,0.0005413742,0.001202144],"category_scores_gemma":[0.009341017,0.0002515213,0.0002772305,0.001233595,0.0009540938,0.0005407886,0.0005793008,0.0006108587,0.0005276597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002033184,"about_ca_system_score_gemma":0.0001698285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000223479,"about_ca_topic_score_gemma":0.0005665835,"domain_scores_codex":[0.9972192,0.001105959,0.0002148273,0.0005411349,0.0007752707,0.0001436006],"domain_scores_gemma":[0.9885243,0.007477037,0.002227719,0.0008181385,0.0005830335,0.0003698164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0011252,0.00008938934,0.1378503,0.0007159434,0.0005486817,0.001073444,0.0004905732,0.001908132,0.8045583,0.001401927,0.0005007115,0.04973738],"study_design_scores_gemma":[0.00006708005,0.000837568,0.590838,0.000119389,0.0004074768,0.006332962,0.0005453211,0.03254198,0.3557352,0.00825353,0.004207679,0.0001137921],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9620134,0.00174612,0.03301658,0.0001100002,0.00007184972,0.00003258851,0.0001368836,0.0002153533,0.002657102],"genre_scores_gemma":[0.9910728,0.0003641235,0.007985609,0.0001189863,0.00002265638,0.00002354749,0.0001409098,0.00005480682,0.0002165102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003928423,"threshold_uncertainty_score":0.02077574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006850778433556958,"score_gpt":0.2340981801582876,"score_spread":0.2272474017247306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}