{"id":"W4244368319","doi":"10.3410/f.1048003.498039","title":"Faculty Opinions recommendation of Mechanism of intracellular block of the KcsA K+ channel by tetrabutylammonium: insights from X-ray crystallography, electrophysiology and replica-exchange molecular dynamics simulations.","year":2006,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Microfluidic and Capillary Electrophoresis Applications","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"KcsA potassium channel; Replica; Electrophysiology; Channel (broadcasting); Molecular dynamics; Block (permutation group theory); Mechanism (biology); Intracellular; Biophysics; Crystallography; Physics; Computer science; Chemical physics; Chemistry; Neuroscience; Ion channel; Biology; Mathematics; Combinatorics; Computational chemistry; Telecommunications; Biochemistry; Quantum mechanics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001237349,0.002519006,0.00129558,0.002412196,0.0005946109,0.001580387,0.003107902,0.003213992,0.02176158],"category_scores_gemma":[0.006432194,0.0006687371,0.001945422,0.003041293,0.0002840718,0.0008725908,0.0008317695,0.001787215,0.02101289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001284153,"about_ca_system_score_gemma":0.002619683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02936279,"about_ca_topic_score_gemma":0.0582929,"domain_scores_codex":[0.9991933,0.0001279617,0.00009434168,0.0002778823,0.0002259947,0.00008066979],"domain_scores_gemma":[0.9976054,0.000852536,0.0003562307,0.0004217732,0.0005542149,0.0002098243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0004865624,0.0001575032,0.006435472,0.002878133,0.0003268691,0.0001013822,0.00003217133,0.004311701,0.0008520002,0.0006565903,0.9749745,0.008787242],"study_design_scores_gemma":[0.002405434,0.0001342891,0.03148881,0.0007266664,0.0005659467,0.0002279257,0.0001125777,0.01588982,0.005724508,0.002813336,0.9397878,0.0001228755],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.0009497802,0.0001704788,0.0001462487,0.0001155463,0.0000233571,0.00001726171,0.9976744,0.0003765045,0.0005264152],"genre_scores_gemma":[0.001722039,0.0001007228,0.0006100566,0.00003837565,0.000005503707,0.00005194463,0.9969753,0.00003432879,0.0004617415],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.02936279,"threshold_uncertainty_score":0.07279968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006188365290091548,"score_gpt":0.2365124000872699,"score_spread":0.2303240347971784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}