{"id":"W4244541582","doi":"10.1073/pnas.0805942105","title":"Isolation of human monoclonal antibodies by mammalian cell display","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Antibody; Monoclonal antibody; Antigen; Immunogenicity; Biology; Immunoglobulin light chain; Virology; Recombinant DNA; Hybridoma technology; Molecular biology; Single-chain variable fragment; Peripheral blood mononuclear cell; Humanized antibody; Phage display; Immunology; In vitro; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006076071,0.0001073325,0.0002483132,0.0001759361,0.0002875727,0.000005994865,0.0004262546,0.00008044107,0.00005191494],"category_scores_gemma":[0.0001330334,0.00006746566,0.0001308738,0.0005178575,0.001626549,0.0002394676,0.0001224363,0.0001917393,0.000002220841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002140249,"about_ca_system_score_gemma":0.00005035471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004206143,"about_ca_topic_score_gemma":7.905227e-8,"domain_scores_codex":[0.9975749,0.000006951699,0.0004193963,0.0002092555,0.001606529,0.0001830026],"domain_scores_gemma":[0.9990659,0.00008852782,0.0003779752,0.000009773842,0.0003975614,0.00006024743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005790509,0.0001127568,0.1786228,0.0001772037,0.00001468534,2.678627e-8,0.000186749,0.000004066373,0.8088122,0.007387024,0.004578938,0.00004565312],"study_design_scores_gemma":[0.0002523487,0.0001819758,0.3280763,0.00008325379,0.00001294171,0.0000248595,0.00008291622,0.0003354553,0.6676656,0.00288805,0.0003334416,0.00006289262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783103,0.0002995266,8.751523e-7,0.00257401,0.00001013837,0.0001639267,0.00004650507,0.000005994814,0.01858871],"genre_scores_gemma":[0.9949267,0.0001223679,0.00147993,0.0001307878,0.00007487276,0.00000375842,0.00000150136,0.000004712495,0.0032554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1494534,"threshold_uncertainty_score":0.5993088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05992325657568462,"score_gpt":0.3480012681566506,"score_spread":0.2880780115809659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}