{"id":"W4244543689","doi":"10.1016/j.jalz.2017.06.2569","title":"[IC‐P‐194]: IN VIVO AND IN VITRO DEMONSTRATION OF [<sup>18</sup>F]THK5351 BINDING TO MONOAMINE OXIDASE–B IN THE HUMAN BRAIN","year":2017,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Advanced MRI Techniques and Applications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill Genome Centre; McGill University","funders":"","keywords":"Monoamine oxidase B; Selegiline; Nuclear medicine; Standardized uptake value; Monoamine oxidase; In vivo; Pharmacology; Medicine; Human brain; Positron emission tomography; Chemistry; Parkinson's disease; Pathology; Biochemistry; Enzyme; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000268315,0.0004780556,0.0003037714,0.000220612,0.0002227933,0.0002715002,0.0006381728,0.0005988117,0.003449684],"category_scores_gemma":[0.0005009085,0.0002610594,0.0002162478,0.0002019349,0.0003141733,0.0002006993,0.0001191945,0.000496964,0.001267167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000371512,"about_ca_system_score_gemma":0.0003350427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005667304,"about_ca_topic_score_gemma":0.003677677,"domain_scores_codex":[0.9997389,0.00009164621,0.00001563978,0.00006626346,0.00002939263,0.00005815268],"domain_scores_gemma":[0.9998141,0.00007268094,0.00002924586,0.00004138038,0.00002004156,0.00002266299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001578426,0.000151857,0.0007487671,0.0001979191,0.00005152512,0.0008632838,0.00007657389,0.0007062429,0.9866456,0.0001694677,0.0005409551,0.008269455],"study_design_scores_gemma":[0.0001716668,0.003261951,0.006816403,0.00002239396,0.00009818741,0.00427145,0.00004377323,0.001640081,0.9782049,0.00008420974,0.005368312,0.00001657225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.964028,0.01247134,0.01003479,0.0003713135,0.00008732486,0.000147077,0.00118619,0.0001570036,0.0115169],"genre_scores_gemma":[0.9865386,0.002268155,0.005843971,0.0001202132,0.00003684365,0.00006062892,0.001601191,0.000057394,0.00347298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005667304,"threshold_uncertainty_score":0.01154035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04259071660021185,"score_gpt":0.3474824490330197,"score_spread":0.3048917324328079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}