{"id":"W4244566352","doi":"10.1016/j.jcf.2017.08.008","title":"CFTR structure","year":2017,"lang":"en","type":"review","venue":"Journal of Cystic Fibrosis","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Association Vaincre la Mucoviscidose; Cystic Fibrosis Canada; Cystic Fibrosis Foundation Therapeutics","keywords":"Cystic fibrosis transmembrane conductance regulator; Cystic fibrosis; Gating; Medicine; Regulator; Transmembrane protein; Potentiator; Drug development; Ion channel; Computational biology; Bioinformatics; Drug; Pharmacology; Internal medicine; Biology; Genetics; Receptor; Physiology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004181707,0.0006311319,0.0009705732,0.001130243,0.0003205326,0.001361537,0.000670316,0.001252722,0.006846929],"category_scores_gemma":[0.0008803013,0.0002253061,0.0004481295,0.0007241378,0.0006205299,0.001165353,0.0009356006,0.001836585,0.003298692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005603961,"about_ca_system_score_gemma":0.001360355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007641409,"about_ca_topic_score_gemma":0.001120144,"domain_scores_codex":[0.9997998,0.0000297303,0.00002688728,0.00003972228,0.00007445286,0.00002939013],"domain_scores_gemma":[0.9998456,0.00004773369,0.00003005638,0.000008985779,0.00004792203,0.00001964246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002041079,0.000047643,0.000592879,0.01162074,0.0001019301,0.0005046653,0.00008548002,0.0002965841,0.008181632,0.01094449,0.07985716,0.8875626],"study_design_scores_gemma":[0.00004355843,0.00006725566,0.0007730761,0.003101639,0.000137897,0.001889308,0.00005372228,0.0001208547,0.001414395,0.002794574,0.9895847,0.00001902151],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005262927,0.9894881,0.0006436738,0.00208934,0.001156399,0.00001779772,0.0001220743,0.00003541852,0.005920952],"genre_scores_gemma":[0.008045287,0.9816251,0.0009353114,0.001894112,0.0009185671,0.00002694517,0.0004019767,0.00001054442,0.006142217],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006846929,"threshold_uncertainty_score":0.02290529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07139341551411288,"score_gpt":0.423052561314754,"score_spread":0.3516591458006411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}