{"id":"W4244566352","doi":"10.1016/j.jcf.2017.08.008","title":"CFTR structure","year":2017,"lang":"en","type":"review","venue":"Journal of Cystic Fibrosis","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Association Vaincre la Mucoviscidose; Cystic Fibrosis Canada; Cystic Fibrosis Foundation Therapeutics","keywords":"Cystic fibrosis transmembrane conductance regulator; Cystic fibrosis; Gating; Medicine; Regulator; Transmembrane protein; Potentiator; Drug development; Ion channel; Computational biology; Bioinformatics; Drug; Pharmacology; Internal medicine; Biology; Genetics; Receptor; Physiology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000560548,0.0005749542,0.004341332,0.0006987891,0.0001673226,0.0001912054,0.0008766629,0.0004735047,0.0005682468],"category_scores_gemma":[0.004477735,0.0003669878,0.001628413,0.0002560672,0.0002630475,0.0002698771,0.0001675485,0.001664967,0.00008776137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004148984,"about_ca_system_score_gemma":0.001964838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005177671,"about_ca_topic_score_gemma":0.00000171568,"domain_scores_codex":[0.9959068,0.0001795153,0.001668094,0.0003317768,0.001376974,0.0005367961],"domain_scores_gemma":[0.9942512,0.0008434322,0.002676249,0.001017003,0.000619134,0.0005929782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001828894,0.00005354509,0.000006012036,0.03190125,0.0006028989,0.0005079696,0.00001628729,8.646371e-7,0.00007739836,0.00001902283,0.009747854,0.956884],"study_design_scores_gemma":[0.000656286,0.0009307284,0.00006221642,0.06219883,0.003090641,0.006250175,0.000007525465,0.000002756545,0.00001448622,0.0001837619,0.9263369,0.0002656382],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000008224682,0.9971187,0.0002366924,0.00008166416,0.0009426026,0.0005474233,0.0002093658,0.00001720312,0.0008381983],"genre_scores_gemma":[0.00002847467,0.9557811,0.04091883,0.00001882718,0.001759116,0.000007033021,0.00004199877,0.000104764,0.001339859],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9566184,"threshold_uncertainty_score":0.9998782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07139341551411288,"score_gpt":0.423052561314754,"score_spread":0.3516591458006411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}