{"id":"W4244852065","doi":"10.21203/rs.3.rs-63987/v1","title":"Rate of protein synthesis is reduced in peripheral blood mononuclear cells (PBMCs) from Fragile X individuals","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Université de Sherbrooke","funders":"","keywords":"Peripheral blood mononuclear cell; Peripheral blood; Peripheral; Immunology; Medicine; Biology; Chemistry; Cell biology; Internal medicine; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001603856,0.0002261886,0.000308301,0.0003315911,0.0001444243,0.0004150629,0.0001982927,0.0004286048,0.00509422],"category_scores_gemma":[0.0007114547,0.0001684866,0.0001757429,0.000210328,0.0001681761,0.0001580076,0.0002588222,0.0005988905,0.001182794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001105085,"about_ca_system_score_gemma":0.0001166034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001109479,"about_ca_topic_score_gemma":0.0005413275,"domain_scores_codex":[0.9997827,0.00003358748,0.0000176023,0.00009002777,0.00003564937,0.0000403509],"domain_scores_gemma":[0.9996669,0.0001099965,0.00006701684,0.00004125344,0.00003190766,0.00008291662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00357729,0.00004939281,0.0128301,0.0000937909,0.00005052224,0.0003366336,0.0001972948,0.00007200277,0.9781532,0.00007271956,0.0005523145,0.004014655],"study_design_scores_gemma":[0.000191937,0.001632409,0.5847478,0.00004146047,0.0001787953,0.004185949,0.0007269551,0.001017537,0.4022812,0.0005461833,0.004408249,0.00004153689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942801,0.001131347,0.0006694003,0.0001847352,0.00005764953,0.000007486628,0.002790042,0.00003193367,0.0008473524],"genre_scores_gemma":[0.9923294,0.0006334439,0.0007798666,0.0001114504,0.00003606335,0.00003652693,0.002977699,0.00003590908,0.003059676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00509422,"threshold_uncertainty_score":0.01704192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03635355234867652,"score_gpt":0.3117475828037942,"score_spread":0.2753940304551177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}