{"id":"W4244969681","doi":"10.1016/j.jalz.2019.06.2809","title":"P2‐402: SYNTHESIS AND <i>IN VIVO</i> BRAIN PET EVALUATION OF 1‐METHYL‐4‐PIPERIDYL <i>P‐</i><sup>18</sup>[F]FLOUROBENZOATE (TRV6501): A BUTYRYLCHOLINESTERASE‐SPECIFIC RADIOLIGAND FOR ALZHEIMER'S DISEASE","year":2019,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Saint Vincent University; Nova Scotia Health Authority; Dalhousie University","funders":"","keywords":"Butyrylcholinesterase; Radioligand; In vivo; Positron emission tomography; Temporal cortex; Neuroscience; Alzheimer's disease; Chemistry; Pathology; White matter; Neuroimaging; Cerebral cortex; Magnetic resonance imaging; Medicine; Nuclear medicine; Psychology; Acetylcholinesterase; Disease; Aché; Biochemistry; Biology; Enzyme; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002872249,0.0007570966,0.0002495069,0.0002181977,0.0002044956,0.000252584,0.0005917284,0.0007316599,0.001378582],"category_scores_gemma":[0.0001280215,0.0003259218,0.000167137,0.0002585082,0.0002626356,0.0003648174,0.0001710338,0.0004889044,0.0008337223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003153611,"about_ca_system_score_gemma":0.0004017274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001699581,"about_ca_topic_score_gemma":0.001328406,"domain_scores_codex":[0.9998952,0.00001917374,0.000005867424,0.0000274297,0.00002264503,0.00002964839],"domain_scores_gemma":[0.9999315,0.000007624881,0.00001552968,0.000008263669,0.00001251567,0.00002462499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003051135,0.00006954258,0.0000440646,0.00006258937,0.000005204048,0.0001250564,0.0000177596,0.0001861521,0.9971174,0.00007175175,0.0001322236,0.001863194],"study_design_scores_gemma":[0.00005151306,0.001130863,0.0005075187,0.00000464434,0.0000140847,0.0004405944,0.00001025106,0.0004749427,0.993721,0.00003099519,0.003602026,0.00001152152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9612202,0.003814619,0.0245096,0.0003444662,0.00006127304,0.0005891031,0.002227939,0.0004480953,0.006784627],"genre_scores_gemma":[0.9457012,0.005793322,0.03029183,0.0002993243,0.0000442329,0.0007785667,0.003633277,0.0002294643,0.01322877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001699581,"threshold_uncertainty_score":0.00461185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04741763382214175,"score_gpt":0.3107205529025094,"score_spread":0.2633029190803676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}