{"id":"W4245192705","doi":"10.1161/circ.116.suppl_16.ii_46-a","title":"Abstract 321: Cardiac Function Improvement Following In vivo Intracoronary Adeno-Associated Virus Type 1 Vector Gene Transfer of SERCA2a in a Pre-Clinical Model of Heart Failure","year":2007,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"","keywords":"Medicine; Heart failure; Internal medicine; Cardiology; Cardiac function curve; Inotrope; In vivo; Lusitropy; Mitral regurgitation; Diastole; Adeno-associated virus; Endocrinology; Blood pressure; Gene; Chemistry; Biology; Vector (molecular biology); Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002587945,0.0005888023,0.0005590796,0.0002551458,0.0001856524,0.0002888754,0.0002999839,0.0005864467,0.0029325],"category_scores_gemma":[0.0001823153,0.0001274082,0.000379085,0.00009539526,0.0004754844,0.0003985093,0.0001647745,0.001061365,0.0005113703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002564628,"about_ca_system_score_gemma":0.0002778158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003806614,"about_ca_topic_score_gemma":0.0003572926,"domain_scores_codex":[0.9998502,0.00002148782,0.00001461609,0.00003677309,0.00002740741,0.00004949399],"domain_scores_gemma":[0.9997965,0.00003264153,0.00005150487,0.00002157391,0.00001942935,0.0000784339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002103228,0.0007575842,0.0002116555,0.00005808943,0.000008856596,0.0001407753,0.00002310364,0.000039027,0.9944554,0.00004376878,0.0001351281,0.002023296],"study_design_scores_gemma":[0.0008396957,0.03975125,0.01168912,0.00002565248,0.00007668705,0.0007534553,0.00007741119,0.001313882,0.9435334,0.00007771024,0.001846598,0.00001519784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974727,0.0004668544,0.0008631644,0.0001132475,0.0001371729,0.00006491692,0.0001833108,0.00007414466,0.0006243694],"genre_scores_gemma":[0.9919533,0.0004659313,0.00155996,0.0001089903,0.0001003847,0.0001898405,0.0008256924,0.00002878457,0.004767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0029325,"threshold_uncertainty_score":0.00981015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0276252482163647,"score_gpt":0.2967454527800458,"score_spread":0.2691202045636811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}