{"id":"W4245213864","doi":"10.21203/rs.3.rs-78228/v1","title":"Modulation of Actin Network and Tau Phosphorylation by HDAC6 ZnF UBP  Domain","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Academy of Scientific and Innovative Research; University of Toronto; National Chemical Laboratory; Department of Biotechnology, Ministry of Science and Technology, India","keywords":"Cell biology; HDAC6; Cytoskeleton; Microtubule; Tau protein; Tauopathy; Phosphorylation; Podosome; Microtubule-associated protein; Immunocytochemistry; Lamellipodium; Actin; Biology; Neurite; Neurofilament; Chemistry; Neurodegeneration; Alzheimer's disease; Cell; Biochemistry; Histone; Pathology; Histone deacetylase; Immunology; Medicine; Disease; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001295158,0.0001902183,0.0001693844,0.0001272864,0.0002206261,0.0002979267,0.0002990635,0.0002177559,0.009896507],"category_scores_gemma":[0.0001623626,0.000124104,0.0001541148,0.0001477454,0.0001801666,0.0002784092,0.0002165812,0.0003915894,0.002042894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003071199,"about_ca_system_score_gemma":0.0001548982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001137326,"about_ca_topic_score_gemma":0.001404321,"domain_scores_codex":[0.9999434,0.000005264536,0.000001907953,0.00001355578,0.00001575193,0.00002011345],"domain_scores_gemma":[0.9999537,0.000005664998,0.000009651772,0.000007765689,0.000006286916,0.00001682992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001077916,0.00005726777,0.000862208,0.00008022055,0.00001391116,0.00007960614,0.00001771486,0.0003767002,0.9874227,0.001246382,0.001224134,0.00754125],"study_design_scores_gemma":[0.0001286825,0.0001178774,0.01869958,0.00001049685,0.00001727431,0.0002220723,0.00004864859,0.006399532,0.963654,0.001041003,0.009652368,0.000008578473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9671226,0.002596684,0.008386242,0.0009030302,0.000153127,0.00002958761,0.003399409,0.0002663606,0.01714291],"genre_scores_gemma":[0.9822129,0.0009190873,0.003450615,0.00005125417,0.00002793434,0.00001819272,0.001593769,0.00007539941,0.01165072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009896507,"threshold_uncertainty_score":0.03310716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07988455247924378,"score_gpt":0.4056226176242085,"score_spread":0.3257380651449647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}