{"id":"W4245286706","doi":"10.1099/mic.0.2007/012427-0","title":"The role of the Serratia marcescens SdeAB multidrug efflux pump and TolC homologue in fluoroquinolone resistance studied via gene-knockout mutagenesis","year":2008,"lang":"en","type":"article","venue":"Microbiology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; University of Manitoba","keywords":"Efflux; Microbiology; Serratia marcescens; Biology; Escherichia coli; Ciprofloxacin; Novobiocin; Bacterial outer membrane; Mutant; Antibiotics; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000225505,0.0002363597,0.0003193301,0.00003392805,0.0002898286,0.000008807077,0.0004939716,0.0002706739,0.000005821268],"category_scores_gemma":[0.0001015563,0.0001563909,0.00009368717,0.0001240751,0.001049082,0.00000381922,0.0003612287,0.0001511341,0.000005393247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002889812,"about_ca_system_score_gemma":0.00007391981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008137483,"about_ca_topic_score_gemma":0.002365436,"domain_scores_codex":[0.9983201,0.0003157362,0.0004236067,0.0004714594,0.00005052163,0.0004185633],"domain_scores_gemma":[0.9989358,0.00006628745,0.0002083306,0.0006727788,0.00008002403,0.00003682161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001662844,0.00004589489,0.06500983,0.00001530587,0.00006657343,0.000007615038,0.000184016,0.000005748778,0.933914,0.00001860065,0.0003404647,0.0002256313],"study_design_scores_gemma":[0.000588226,0.0000681185,0.2211891,0.00002233087,0.00001731323,0.0001438538,0.0001552907,0.000007955226,0.7623463,0.0000476998,0.0152196,0.0001942619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993807,0.005069234,0.00004050395,0.0002964516,0.0002184631,0.0003579361,0.00006598789,0.000008621922,0.0001357883],"genre_scores_gemma":[0.9964707,0.001346344,0.0004140215,0.0001150647,0.00006893589,0.00001561444,0.00004804877,0.0000242816,0.001496942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1715677,"threshold_uncertainty_score":0.6377437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004784203750869161,"score_gpt":0.1969455946716746,"score_spread":0.1921613909208055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}